DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28F and SERPINB5

DIOPT Version :9

Sequence 1:	NP_524957.2	Gene:	Spn28F / 49807	FlyBaseID:	FBgn0028987	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_002630.2	Gene:	SERPINB5 / 5268	HGNCID:	8949	Length:	375	Species:	Homo sapiens

Alignment Length:	388	Identity:	118/388 - (30%)
Similarity:	201/388 - (51%)	Gaps:	37/388 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLLATSVSCRFADDFYQLLAKENAANNLISSPLSVEIALSMAYMGARAKTAQEMRNVLKLPDDKK 71
            |.||.|.   ||.|.::.|.::....|::.||:.:..:||:|.:||:..||.|:..||.. ::.|
Human     4 LQLANSA---FAVDLFKQLCEKEPLGNVLFSPICLSTSLSLAQVGAKGDTANEIGQVLHF-ENVK 64

  Fly    72 EVAAKYKDLLSKLEGREKVATLSLANRIYVNKKFQLVPSYNQMVKDSFMAEAEAIDIVDP-NKAS 135
            :|...::.:.|.:.......:|.|..|:||:|...|...:....|..:..|.|.:|..|. .:..
Human    65 DVPFGFQTVTSDVNKLSSFYSLKLIKRLYVDKSLNLSTEFISSTKRPYAKELETVDFKDKLEETK 129

  Fly   136 SIVNNWVDNQTRGKIKDLVSSNDMS-KMELIVLNAIYFKGQWEYKFNPKLTKKRNFRVSDQKSVP 199
            ..:||.:.:.|.|..:::::.|.:: :.:::|:||.||.|:|..||:...||:..|||:...:.|
Human   130 GQINNSIKDLTDGHFENILADNSVNDQTKILVVNAAYFVGKWMKKFSESETKECPFRVNKTDTKP 194

  Fly   200 VEMMSLFQSFRAAHDSELGAKIIELPYRNSSLSMLIFLP----DQVDGLSELEKKIVG------F 254
            |:||::..:|...:...:..||||||::|..|||.|.||    |:..||.::||::..      .
Human   195 VQMMNMEATFCMGNIDSINCKIIELPFQNKHLSMFILLPKDVEDESTGLEKIEKQLNSESLSQWT 259

  Fly   255 KPK-LSKMDVTLRLPKFKIEFFAQLNKVLVAMGIQDAF-EKSADFKDLVENSNVHVKKVIHKAFI 317
            .|. ::...|.|.:||||:|........|..:|::..| |.::||..:.|...|.:..||||..:
Human   260 NPSTMANAKVKLSIPKFKVEKMIDPKACLENLGLKHIFSEDTSDFSGMSETKGVALSNVIHKVCL 324

  Fly   318 EVNEEGAEAAAATALLFVRYSMPMPSSQMV-----FNADHPFAYVIRDRET--IYFQGHFVKP 373
            |:.|:|.:            |:.:|.::::     .||||||.|:||..:|  |.|.|.|..|
Human   325 EITEDGGD------------SIEVPGARILQHKDELNADHPFIYIIRHNKTRNIIFFGKFCSP 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	SERPIN	14..370	CDD:238101	112/376 (30%)
SERPINB5	NP_002630.2	maspin_like	4..375	CDD:239012	117/386 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.930