DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28F and SERPINF1

DIOPT Version :9

Sequence 1:	NP_524957.2	Gene:	Spn28F / 49807	FlyBaseID:	FBgn0028987	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_001316832.1	Gene:	SERPINF1 / 5176	HGNCID:	8824	Length:	418	Species:	Homo sapiens

Alignment Length:	387	Identity:	109/387 - (28%)
Similarity:	190/387 - (49%)	Gaps:	47/387 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LATSVSCRFADDFYQLLAKENAANNLISSPLSVEIALSMAYMGARAKTAQEMR-----NVLKLPD 68
            ||.:|| .|..|.|::.:..:...|::.|||||..|||...:||..:|...:.     :::..||
Human    54 LAAAVS-NFGYDLYRVRSSTSPTTNVLLSPLSVATALSALSLGAEQRTESIIHRALYYDLISSPD 117

  Fly    69 DKKEVAAKYKDLLSKLEGREKVATLSLANRIYVNKKFQLVPSYNQMVKDSFMAEAE-------AI 126
                :...||:||..:...:|  .|..|:||...||.:        :|.||:|..|       .:
Human   118 ----IHGTYKELLDTVTAPQK--NLKSASRIVFEKKLR--------IKSSFVAPLEKSYGTRPRV 168

  Fly   127 DIVDPNKASSIVNNWVDNQTRGKIKDLVSSNDM-SKMELIVLNAIYFKGQWEYKFNPKLTKKRNF 190
            ...:|......:||||..|.:||:..  |:.:: .::.:::|...:|||||..||:.:.|...:|
Human   169 LTGNPRLDLQEINNWVQAQMKGKLAR--STKEIPDEISILLLGVAHFKGQWVTKFDSRKTSLEDF 231

  Fly   191 RVSDQKSVPVEMMSLFQS-FRAAHDSELGAKIIELPYRNSSLSMLIFLPDQV-DGLSELEKKIVG 253
            .:.::::|.|.|||..:: .|...||:|..||.:||. ..|:|::.|||.:| ..|:.:|:.:..
Human   232 YLDEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPL-TGSMSIIFFLPLKVTQNLTLIEESLTS 295

  Fly   254 -----FKPKLSKMDVTLRLPKFKIEFFAQLNKVLVAMGIQDAFEKSADFKDLVENSNVHVKKVIH 313
                 ...:|..:...|.:||.|:.:..::.|.|..|.:|..|: |.||.. :....:.:.:|.|
Human   296 EFIHDIDRELKTVQAVLTVPKLKLSYEGEVTKSLQEMKLQSLFD-SPDFSK-ITGKPIKLTQVEH 358

  Fly   314 KAFIEVNEEGAEAAAATALLFVRYSMPMPSSQMVFNADHPFAYVIRDRET--IYFQGHFVKP 373
            :|..|.||:||....:..|.....:.|:.     ::.:.||.:|:||.:|  :.|.|..:.|
Human   359 RAGFEWNEDGAGTTPSPGLQPAHLTFPLD-----YHLNQPFIFVLRDTDTGALLFIGKILDP 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	SERPIN	14..370	CDD:238101	105/377 (28%)
SERPINF1	NP_001316832.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..39
		PEDF	40..415	CDD:239007	108/385 (28%)
		O-glycosylated at one site	371..383		1/11 (9%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010