DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28F and SERPINA5

DIOPT Version :9

Sequence 1:	NP_524957.2	Gene:	Spn28F / 49807	FlyBaseID:	FBgn0028987	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_000615.3	Gene:	SERPINA5 / 5104	HGNCID:	8723	Length:	406	Species:	Homo sapiens

Alignment Length:	409	Identity:	129/409 - (31%)
Similarity:	204/409 - (49%)	Gaps:	48/409 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LCLLLL----------------------------ATSVSCRFADDFYQLLAKENAANNLISSPLS 40
            |||:||                            |.|....|..|.|:.||....:.::..||:|
Human     7 LCLVLLSPQGASLHRHHPREMKKRVEDLHVGATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVS 71

  Fly    41 VEIALSMAYMGARAKTAQEMRNVLKL---PDDKKEVAAKYKDLLSKLEGREKVATLSLANRIYVN 102
            :.::|:|..:||.:.|..::...|.|   ...:||:...::.||.:|........|||.|.::.:
Human    72 ISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTD 136

  Fly   103 KKFQLVPSYNQMVKDSFMAEAEAIDIVDPNKASSIVNNWVDNQTRGKIKDLVSSNDMSKMELIVL 167
            ....|..::...:|..::|:....:..|...|...:|::|..||:|||.||:.:.| |...:|::
Human   137 LVVDLQDTFVSAMKTLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLD-SNAVVIMV 200

  Fly   168 NAIYFKGQWEYKFNPKLTKKRNFRVSDQKSVPVEMMSLFQSFRAAHDSELGAKIIELPYRNSSLS 232
            |.|:||.:||..||.|.|::::|.|:.:..|.|.|||....:....|..|..:::.:||:.::.:
Human   201 NYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATA 265

  Fly   233 MLIFLP-----DQVD-GLSE--LEKKIVGFKPKLSKMDVTLRLPKFKIEFFAQLNKVLVAMGIQD 289
            :.| ||     .||: ||||  |.|.:..||    |..:.|.||||.||...||.|||.::||.:
Human   266 LFI-LPSEGKMQQVENGLSEKTLRKWLKMFK----KRQLELYLPKFSIEGSYQLEKVLPSLGISN 325

  Fly   290 AFEKSADFKDLVENSNVHVKKVIHKAFIEVNEEGAEAAAATALLFVRYSMPMPSSQMVFNADHPF 354
            .|...||...:..:||:.|.:::|||.:||:|.|..|||||..:|...|..:.|.::|||  .||
Human   326 VFTSHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFN--RPF 388

  Fly   355 AYVIRDRETIYFQGHFVKP 373
            ...|.| ..|.|.|...:|
Human   389 LMFIVD-NNILFLGKVNRP 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	SERPIN	14..370	CDD:238101	121/366 (33%)
SERPINA5	NP_000615.3	alpha-1-antitrypsin_like	44..403	CDD:239011	121/367 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010