Protein Alignment Spn28F and SERPINB2

DIOPT Version :9

• Sequence 1: NP_524957.2
• Gene: Spn28F / 49807
• FlyBaseID: FBgn0028987
• Length: 375
• Species: Drosophila melanogaster
• Sequence 2: NP_001137290.1
• Gene: SERPINB2 / 5055
• HGNCID: 8584
• Length: 415
• Species: Homo sapiens
• Alignment Length: 430
• Identity: 126/430 - (29%)
• Similarity: 212/430 - (49%)
• Gaps: 72/430 - (16%)

  Fly     1 MKHLCLLLLATSVSCRFADDFYQLLAKENAANNLISSPLSVEIALSMAYMGARAKTAQEMRNVLK 65
            |:.||:      .:..||.:.::.|||.:...||..||.|:...::|.|||:|..|..:|..||:
Human     1 MEDLCV------ANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQ 59

  Fly    66 LPDDKKEVAA-----------------------KYKDLLSKLEGREKVAT--------------- 92
            .    .||.|                       .|.|.:.:.:..:|:.:
Human    60 F----NEVGANAVTPMTPENFTSCGFMQQIQKGSYPDAILQAQAADKIHSSFRSLSSAINASTGN 120

  Fly    93 --LSLANRIYVNKKFQLVPSYNQMVKDSFMAEAEAIDIVD-PNKASSIVNNWVDNQTRGKIKDLV 154
              |...|:::..|.......|.::.:..:.:|.:|:|.:: ..:|...:|:||..||:|||.:|:
Human   121 YLLESVNKLFGEKSASFREEYIRLCQKYYSSEPQAVDFLECAEEARKKINSWVKTQTKGKIPNLL 185

  Fly   155 SSNDM-SKMELIVLNAIYFKGQWEYKFNPKLTKKRNFRVSDQKSVPVEMMSLFQSFRAAHDSELG 218
            ....: ....::::||:||||:|:..|..||.....|||:..:..||:||.|.:.....:..:|.
Human   186 PEGSVDGDTRMVLVNAVYFKGKWKTPFEKKLNGLYPFRVNSAQRTPVQMMYLREKLNIGYIEDLK 250

  Fly   219 AKIIELPYRNSSLSMLIFLPDQV----DGLSELEKKIV-------GFKPKLSKMDVTLRLPKFKI 272
            |:|:||||. ..:||.:.|||::    .||..||.:|.       ..|.|:::.:|.:.:|:||:
Human   251 AQILELPYA-GDVSMFLLLPDEIADVSTGLELLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKL 314

  Fly   273 EFFAQLNKVLVAMGIQDAFEKS-ADFKDLVENSNVHVKKVIHKAFIEVNEEGAEAAAAT-ALLFV 335
            |...:|..:|.:||::|||.|. |:|..:.|.:::.:.:|.|:|.::|||||.||||.| .::..
Human   315 EEHYELRSILRSMGMEDAFNKGRANFSGMSERNDLFLSEVFHQAMVDVNEEGTEAAAGTGGVMTG 379

  Fly   336 RYSMPMPSSQMVFNADHPFAYVIRDRET--IYFQGHFVKP 373
            |.....|.    |.|||||.::|..:.|  |.|.|.|..|
Human   380 RTGHGGPQ----FVADHPFLFLIMHKITNCILFFGRFSSP 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	SERPIN	14..370	CDD:238101	121/412 (29%)
SERPINB2	NP_001137290.1	PAI-2	4..415	CDD:239013	124/425 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.930