Protein Alignment Spn28F and SERPINE1

DIOPT Version :10

• Sequence 1: NP_524957.2
• Gene: Spn28F / 49807
• FlyBaseID: FBgn0028987
• Length: 375
• Species: Drosophila melanogaster
• Sequence 2: NP_001373389.1
• Gene: SERPINE1 / 5054
• HGNCID: 8583
• Length: 492
• Species: Homo sapiens
• Alignment Length: 373
• Identity: 107/373 - (28%)
• Similarity: 179/373 - (47%)
• Gaps: 32/373 - (8%)

  Fly    12 SVSCRFADDF----YQLLAKENAANNLISSPLSVEIALSMAYMGARAKTAQEMRNVLKLPDDKKE 72
            |.....|.||    :|.:|:.:...|::.||..|...|:|..:....:|.|:::..:....|.|.
Human    29 SYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKG 93

  Fly    73 VAAKYKDLLSKLEGREKVATLSLANRIYVNKKFQLVPSYNQMVKDSFMAEAEAIDIVDPNKASSI 137
            :|...:.|..:|.|......:|..:.|:|.:..:||..:.......|.:..:.:|..:..:|..|
Human    94 MAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFI 158

  Fly   138 VNNWVDNQTRGKIKDLVSSNDMSKM-ELIVLNAIYFKGQWEYKFNPKLTKKRNFRVSDQKSVPVE 201
            :|:||...|:|.|.:|:....:.:: .|:::||:||.|||:..|....|.:|.|..||..:|.|.
Human   159 INDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVP 223

  Fly   202 MMSLFQSFRAA---------HDSELGAKIIELPYRNSSLSMLIFLPDQVD-GLSEL-----EKKI 251
            ||:....|...         :|      |:||||...:|||.|..|.:.: .||.|     .:.|
Human   224 MMAQTNKFNYTEFTTPDGHYYD------ILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLI 282

  Fly   252 VGFKPKLSKMDVTLRLPKFKIEFFAQLNKVLVAMGIQDAFEK-SADFKDLVENSNVHVKKVIHKA 315
            ..:|..::::...|.||||.:|....|.|.|..:|:.|.|.: .|||..|.:...:||.:.:.|.
Human   283 SHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKV 347

  Fly   316 FIEVNEEGAEAAAATALLFVRYSMPMPSSQMVFNADHPFAYVIRDRET 363
            .|||||.|..|:::||::   .|..|...:::.  |.||.:|:|...|
Human   348 KIEVNESGTVASSSTAVI---VSARMAPEEIIM--DRPFLFVVRHNPT 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	serpin42Dd-like_insects	12..373	CDD:381070	107/373 (29%)
SERPINE1	NP_001373389.1	serpinE1_PAI-1	29..393	CDD:381007	107/373 (29%)