DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28F and serpinb1l1

DIOPT Version :9

Sequence 1:	NP_524957.2	Gene:	Spn28F / 49807	FlyBaseID:	FBgn0028987	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_001009892.2	Gene:	serpinb1l1 / 494155	ZFINID:	ZDB-GENE-040715-5	Length:	384	Species:	Danio rerio

Alignment Length:	385	Identity:	133/385 - (34%)
Similarity:	226/385 - (58%)	Gaps:	27/385 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TSVSCRFADDFYQLLAKENAANNLISSPLSVEIALSMAYMGARAKTAQEMRNVL----KLPDDKK 71
            ::.:.:|:.:.::.::..||:.|:..||:|:..||:|..:||:..||.:|..||    :.....:
Zfish     5 SAANTQFSLNLFKKISGGNASGNVFYSPVSISSALAMVSLGAKGNTADQMFKVLGFNSQAHQPVE 69

  Fly    72 EVAAKYKDLLSKLEGREKVATLSLANRIYVNKKFQLVPSYNQMVKDSFMAEAEAIDIVDPNKASS 136
            ::.:.:|..:|:|...|....||||||:|..:.:||:..:....|..:.|..|.:|.::.::.:.
Zfish    70 QIHSNFKKFMSELNKPEAPYVLSLANRLYGEQTYQLIEKFLNDTKRYYDAGLEKVDFINKSEDAR 134

  Fly   137 I-VNNWVDNQTRGKIKDLVSSNDMSKM-ELIVLNAIYFKGQWEYKFNPKLTKKRNFRVSDQKSVP 199
            : :|.||:..|:.|||||:.|..:..| .|:::|||||||.||.||..:.|:...||::..::.|
Zfish   135 VNINTWVEKNTQEKIKDLLPSGAIDAMTRLVLVNAIYFKGNWEEKFPKEATRDGVFRLNKNQTKP 199

  Fly   200 VEMMSLFQSFRAAHDSELGAKIIELPYRNSSLSMLIFLPDQVD----GLSELEK-----KIVGF- 254
            |:||.....|.:.:..|:.:.::||||...:|||||.|||:::    ||.:||:     |::.:
Zfish   200 VKMMHQKAEFPSGYIEEMKSHVLELPYAGKNLSMLIILPDEIEDETTGLQKLERALTYEKLMEWT 264

  Fly   255 KPK-LSKMDVTLRLPKFKIEFFAQLNKVLVAMGIQDAFE-KSADFKDLVENSNVHVKKVIHKAFI 317
            ||: :.:.:|.:.|||||.|....:..:||:||::|.|: :..:...:..::::.:.|.|||||:
Zfish   265 KPEVMHQREVQVSLPKFKTEQTYDMKSLLVSMGMEDVFDPQKVNLTGMSSSNDLVLSKAIHKAFV 329

  Fly   318 EVNEEGAEAAAATALL--FVRYSMPMPSSQMVFNADHPFAYVIRDRET--IYFQGHFVKP 373
            ||||||.|||||||.:  .:.|..|:.     |||||||.:.||...|  |.|.|....|
Zfish   330 EVNEEGTEAAAATAAIEKLMCYIPPLS-----FNADHPFLFFIRHNPTKSILFYGRLCSP 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	SERPIN	14..370	CDD:238101	132/377 (35%)
serpinb1l1	NP_001009892.2	PAI-2	4..384	CDD:239013	132/383 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	229	1.000	Inparanoid score	I3432
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.880