Protein Alignment Spn28F and SERPINC1

DIOPT Version :10

• Sequence 1: NP_524957.2
• Gene: Spn28F / 49807
• FlyBaseID: FBgn0028987
• Length: 375
• Species: Drosophila melanogaster
• Sequence 2: NP_001373231.1
• Gene: SERPINC1 / 462
• HGNCID: 775
• Length: 505
• Species: Homo sapiens
• Alignment Length: 427
• Identity: 121/427 - (28%)
• Similarity: 209/427 - (48%)
• Gaps: 72/427 - (16%)

  Fly    11 TSVSCRFADDFYQLLA-KENAANNLISSPLSVEIALSMAYMGARAKTAQEMRNVLKLPDDKKEVA 74
            :..:.|||..|||.|| .:|..:|:..||||:..|.:|..:||...|.|::..|.|.....::.:
Human    84 SKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTS 148

  Fly    75 AKYKDLLSKLEGR-----EKVATLSLANRIYVNKKFQLVPSYNQMVKDSFMAEAEAIDIVD-PNK 133
            .:.....:||..|     .|.:.|..|||::.:|......:|..:.:..:.|:.:.:|..: ..:
Human   149 DQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQ 213

  Fly   134 ASSIVNNWVDNQTRGKIKDLVSSNDMSKMELIVL-NAIYFK------------------------ 173
            :.:.:|.||.|:|.|:|.|::.|..::::.::|| |.||||
Human   214 SRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKVLRMALERPQGLPLALQLTPFFFK 278

  Fly   174 -----------------GQWEYKFNPKLTKKRNFRVSDQKSVPVEMMSLFQSFRAAHDSELGAKI 221
                             |.|:.||:|:.|:|..|..:|.:|....||.....||....:| |.::
Human   279 WRDRSPERANGLPKATQGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAE-GTQV 342

  Fly   222 IELPYRNSSLSMLIFLPDQVDGLSELEKKIV-----GFKPKLSKMDVTLRLPKFKIEFFAQLNKV 281
            :|||::...::|::.||.....|:::||::.     .:..:|.:|.:.:.:|:|:||....|.:.
Human   343 LELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQ 407

  Fly   282 LVAMGIQDAF--EKS------ADFKDLVENSNVHVKKVIHKAFIEVNEEGAEAAAATALLFVRYS 338
            |..||:.|.|  |||      |:.:|     :::|....||||:||||||:||||:||::....|
Human   408 LQDMGLVDLFSPEKSKLPGIVAEGRD-----DLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRS 467

  Fly   339 MPMPSSQMVFNADHPFAYVIRD--RETIYFQGHFVKP 373
              :..:::.|.|:.||...||:  ..||.|.|....|
Human   468 --LNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANP 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	serpin42Dd-like_insects	12..373	CDD:381070	120/424 (28%)
SERPINC1	NP_001373231.1	serpinC1_AT3	70..504	CDD:381002	121/427 (28%)