DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28F and serpinb1

DIOPT Version :9

Sequence 1:	NP_524957.2	Gene:	Spn28F / 49807	FlyBaseID:	FBgn0028987	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_001002653.1	Gene:	serpinb1 / 436926	ZFINID:	ZDB-GENE-040718-400	Length:	380	Species:	Danio rerio

Alignment Length:	377	Identity:	135/377 - (35%)
Similarity:	209/377 - (55%)	Gaps:	26/377 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FADDFYQLLAKENAANNLISSPLSVEIALSMAYMGARAKTAQEMRNVLKLPDDKKEVAAKYKDLL 81
            ||.|.|:.|:..:|..|:..||||:..||||.|:|||..||.||..||.. ....:|.:.::.|:
Zfish    11 FALDLYRALSASSAEGNIFFSPLSISAALSMVYLGARGDTAGEMEKVLSF-SSVSDVHSHFESLI 74

  Fly    82 SKLEGREKVATLSLANRIYVNKKFQLVPSYNQMVKDSFMAEAEAIDIVDPNKAS-SIVNNWVDNQ 145
            |.:........|.||||:|..|.|..:|.|.....:.:.|:.:|:|.:..::.| .::|.||:.|
Zfish    75 SSINSPSASYILRLANRLYGEKTFSFLPEYLSSSLNLYHADLQAVDFIGASEQSRQLINKWVEEQ 139

  Fly   146 TRGKIKDLVSSNDMSKM-ELIVLNAIYFKGQWEYKFNPKLTKKRNFRVSDQKSVPVEMMSLFQSF 209
            |..||:||:....::.| .|.::|||||||.|..:||.:.||:..|:::.:::.||:||...:.|
Zfish   140 TENKIRDLLKPGMVTGMTRLALVNAIYFKGNWLQRFNAQDTKEMPFKINQKENRPVQMMYQKKKF 204

  Fly   210 RAAHDSELGAKIIELPYRNSSLSMLIFLPDQV----DGLSELEKKIVGFKPKL----------SK 260
            ...:..:...:::||||....|||||.||::.    |.|.:||.::.  ..||          ::
Zfish   205 PFNYIYDHRVQVLELPYVKEELSMLILLPEETQDGSDPLLKLESELT--IDKLHEWTNRNNMDTQ 267

  Fly   261 MDVTLRLPKFKIEFFAQLNKVLVAMGIQDAF-EKSADFKDLVENSNVHVKKVIHKAFIEVNEEGA 324
            .|:.:.||:||:|..:.|.::|:.||:...| |..||...:..:..:.:..|.||||::|||||.
Zfish   268 TDIIVHLPRFKLEIESSLVEILMGMGMSSVFQEGKADLTGMTGHGGLFLSAVAHKAFVDVNEEGT 332

  Fly   325 EAAAATALLFVRYSMPMPSSQMVFNADHPFAYVIRDRET--IYFQGHFVKPN 374
            |||||||.: |.:.|   ..:..|.|||||.:.||...|  |.|.|.|..|:
Zfish   333 EAAAATAAI-VAFCM---LREEHFMADHPFLFYIRHNPTNSILFFGRFRGPS 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	SERPIN	14..370	CDD:238101	133/371 (36%)
serpinb1	NP_001002653.1	SERPIN	5..379	CDD:294093	134/374 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	229	1.000	Domainoid score	I2400
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	229	1.000	Inparanoid score	I3432
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.980