DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28F and Serpinb6b

DIOPT Version :9

Sequence 1:	NP_524957.2	Gene:	Spn28F / 49807	FlyBaseID:	FBgn0028987	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	XP_038951899.1	Gene:	Serpinb6b / 364705	RGDID:	1310452	Length:	388	Species:	Rattus norvegicus

Alignment Length:	386	Identity:	133/386 - (34%)
Similarity:	209/386 - (54%)	Gaps:	37/386 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FADDFYQLLAKENAANNLISSPLSVEIALSMAYMGARAKTAQEMRNVLKLPDDK------KEVAA 75
            ||.:..:.|. |:::.|::.||||:...|:|.:|||:..||.:|...|.|  ||      ::|..
  Rat    11 FAFNLLKTLG-EDSSKNVLFSPLSISSGLAMVFMGAKGTTAHQMIQALSL--DKCSGRGSRDVHQ 72

  Fly    76 KYKDLLSKLEGREKVATLSLANRIYVNKKFQLVPSYNQMVKDSFMAEAEAIDIVD-PNKASSIVN 139
            .::.||:|:........|..|||::..|.|.::.|:....:..:.||.|.:|... |.::...:|
  Rat    73 GFQSLLAKVNKTGTQYLLKTANRLFGEKTFDILASFKDACRKFYEAEMEELDFKGAPEQSRQHIN 137

  Fly   140 NWVDNQTRG-----------KIKDLVSSNDM-SKMELIVLNAIYFKGQWEYKFNPKLTKKRNFRV 192
            .||..:|.|           ||.:|:||..: :...|:::|||||||.|:.:||.:.|::..|:|
  Rat   138 TWVAKKTEGQSISLNWNSQKKITELLSSGSVNANTPLVLVNAIYFKGNWKKQFNKEDTQEMPFKV 202

  Fly   193 SDQKSVPVEMMSLFQSFRAAHDSELGAKIIELPYRNSSLSMLIFLPDQVDGLSELEKKIVGFK-- 255
            :..:..||:||....:|:..:..|:...|:.|||..:.|:|:|.|||:...|..:||:|...|
  Rat   203 TKNEEKPVKMMFKKSTFKMTYVEEISTTILLLPYVGNELNMIIMLPDEHIELRMVEKEITYKKFI 267

  Fly   256 -----PKLSKMDVTLRLPKFKIEFFAQLNKVLVAMGIQDAFEKS-ADFKDLVENSNVHVKKVIHK 314
                 .|:.:.:|.:.|||||:|....:..||..:|:.||||:. |||..:.....:.:.|||||
  Rat   268 EWTSLDKMEEREVEVFLPKFKLEENHDMKDVLHRLGMTDAFEQGMADFSGIASKEGLFLSKVIHK 332

  Fly   315 AFIEVNEEGAEAAAATALLFVRYSMPMPSSQMVFNADHPFAYVIRDRET--IYFQGHFVKP 373
            :|:||||||.||||||| ..|.:...:|    .|.|:|||.:.|:...|  |.|.|.|..|
  Rat   333 SFVEVNEEGTEAAAATA-ANVTFRCMVP----YFCANHPFLFFIQHSRTNGIVFCGRFSSP 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	SERPIN	14..370	CDD:238101	131/381 (34%)
Serpinb6b	XP_038951899.1	serpin	1..388	CDD:422956	132/384 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.830