DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28F and serpinc1

DIOPT Version :9

Sequence 1:	NP_524957.2	Gene:	Spn28F / 49807	FlyBaseID:	FBgn0028987	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_878283.1	Gene:	serpinc1 / 321545	ZFINID:	ZDB-GENE-030131-264	Length:	450	Species:	Danio rerio

Alignment Length:	383	Identity:	122/383 - (31%)
Similarity:	201/383 - (52%)	Gaps:	23/383 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TSVSCRFADDFYQLLAKENAAN--NLISSPLSVEIALSMAYMGARAKTAQEMRNVLKLPDDKKEV 73
            :..:.|||...::.|| |..:|  |:..||:|:..|.:|..:||...|.:::..|.:....|::.
Zfish    67 SKANSRFALSLFKQLA-EGKSNDENIFLSPISISTAFAMTKLGACNTTLEQLMKVFQFDTIKEKT 130

  Fly    74 AAKYKDLLSKLE---GREKVATLSL--ANRIYVNKKFQLVPSYNQMVKDSFMAEAEAIDIVDPNK 133
            :.:.....:||.   .|:|..|..|  |||::.:|......::..:.:..:.|:...:|..:..:
Zfish   131 SDQVHFFFAKLNCRLYRKKHETTELISANRLFGDKSTTFNETFQHISETVYGAKLMPLDFKEKPE 195

  Fly   134 ASSI-VNNWVDNQTRGKIKDLVSSNDMSKMELIVL-NAIYFKGQWEYKFNPKLTKKRNFRVSDQK 196
            ||.| :|.|:.|:|..:|||.:....:....::|| |||||||||:.||:.:...|.:|.||...
Zfish   196 ASRITINEWIANKTENRIKDTLPEGSIDTNTILVLVNAIYFKGQWKNKFDKQNVMKLDFHVSPTH 260

  Fly   197 SVPVEMMSLFQSFRAAHDSELGAKIIELPYRNSSLSMLIFLPDQVDGLSELE-----KKIVGFKP 256
            ..||.||...:.|:.|...|...||:||||....::|::.||.:...|||:.     ||:||:..
Zfish   261 KCPVPMMYQEKKFQYAKIPEDKVKILELPYNGGDITMVLILPIEGATLSEVVANMNLKKLVGWLH 325

  Fly   257 KLSKMDVTLRLPKFKIEFFAQLNKVLVAMGIQDAFE-KSADFKDLV---ENSNVHVKKVIHKAFI 317
            .:.:..|.:::|:|::|....|.:.|..||::|.|. .:|....:|   |..|:.:....||||:
Zfish   326 AMKETTVAVQIPRFRVEDSFSLKEQLTKMGLEDLFSPANASLPGMVADAEGPNLFISDAYHKAFL 390

  Fly   318 EVNEEGAEAAAATALLFVRYSMPMPSSQMVFNADHPFAYVIRDR--ETIYFQGHFVKP 373
            ||||||:||:||||::....|:.:...|.|  ||.||...||:.  ..:.|.|....|
Zfish   391 EVNEEGSEASAATAVVATGRSLNIFREQFV--ADRPFLLFIRESSINALIFTGRVANP 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	SERPIN	14..370	CDD:238101	121/375 (32%)
serpinc1	NP_878283.1	antithrombin-III_like	62..443	CDD:239000	121/378 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.890