DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn28F and SERPIND1

DIOPT Version :9

Sequence 1:	NP_524957.2	Gene:	Spn28F / 49807	FlyBaseID:	FBgn0028987	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_000176.2	Gene:	SERPIND1 / 3053	HGNCID:	4838	Length:	499	Species:	Homo sapiens

Alignment Length:	378	Identity:	111/378 - (29%)
Similarity:	199/378 - (52%)	Gaps:	25/378 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VSCRFADDFYQLLAKE-NAANNLISSPLSVEIALSMAYMGARAKTAQEMRNVLKLPD-----DKK 71
            ::.:||.:.|::|..: |..:|:..:|:.:..|:.|..:|.:.:|.:::.::|...|     .|.
Human   129 LNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKY 193

  Fly    72 EVAA---KYKDLLSKLEGREKVATLSLANRIYVNKKFQLVPSYNQMVKDSFMAEAEAIDIVDPNK 133
            |:..   .::.|..:|..|....||...|.:|:.|:|.::..:...|::.:.|||:..|..||..
Human   194 EITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAF 258

  Fly   134 ASSIVNNWVDNQTRGKIKDLVSSNDMSKMELIVLNAIYFKGQWEYKFNPKLTKKRNFRVSDQKSV 198
            .|. .||.:...|:|.|||.:.:.|.: .::::||.|||||.|..||..::|...|||:::::.|
Human   259 ISK-TNNHIMKLTKGLIKDALENIDPA-TQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVV 321

  Fly   199 PVEMMSLFQSFRAAHDSELGAKIIELPYRNSSLSMLIFLPDQVDGLSELEKKIV-----GFKPKL 258
            .|.||....:|.||:|.||...|::|.| ...:||||.:|.::.|:..||.::.     .::..:
Human   322 KVSMMQTKGNFLAANDQELDCDILQLEY-VGGISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSM 385

  Fly   259 SKMDVTLRLPKFKIEFFAQLNKVLVAMGIQDAFEKSADFKDLVENSNVHVKKVIHKAFIEVNEEG 323
            :.....:.|||||:|....|.:.|..|||:..|:|:.:... :.:..:.:....|:..|.|||||
Human   386 TNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAG-ISDQRIAIDLFKHQGTITVNEEG 449

  Fly   324 AEAAAATALLFVRYSMPMPSSQMVFNADHPFAYVIRDRET--IYFQGHFVKPN 374
            .:|...|.:.|    ||: |:|:.|..|.||.::|.:..|  :.|.|....|:
Human   450 TQATTVTTVGF----MPL-STQVRFTVDRPFLFLIYEHRTSCLLFMGRVANPS 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	SERPIN	14..370	CDD:238101	110/371 (30%)
SERPIND1	NP_000176.2	HCII	62..497	CDD:239002	110/376 (29%)
		Chemotactic activity	68..79
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	73..97
		Glycosaminoglycan-binding site	192..212		4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020