DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28F and Serpinb12

DIOPT Version :9

Sequence 1:	NP_524957.2	Gene:	Spn28F / 49807	FlyBaseID:	FBgn0028987	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	XP_038946584.1	Gene:	Serpinb12 / 304692	RGDID:	1566382	Length:	423	Species:	Rattus norvegicus

Alignment Length:	417	Identity:	134/417 - (32%)
Similarity:	217/417 - (52%)	Gaps:	62/417 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RFADDFYQLLAKENAANNLISSPLSVEIALSMAYMGARAKTAQEMRNVL---KLPDDKK----EV 73
            :|..||:|.::|::|..|:...|||:..|..|..:|||..:||::..||   :||.|::    |.
  Rat    10 KFCFDFFQEISKDDAHKNIFVCPLSLSAAFGMVRLGARGDSAQQIDEVLHFNELPKDERKEPSEP 74

  Fly    74 AAKYKDLLSKLEGREKVA------------------------------------TLSLANRIYVN 102
            ::|.|...|.|||:::..                                    |||:|||:|..
  Rat    75 SSKSKASDSSLEGQKQTTASQGQQVSGESTNEHRLLGCHFGKLLSRIDRDKAHYTLSMANRLYGE 139

  Fly   103 KKFQLVPSYNQMVKDSFMAEAEAIDI-VDPNKASSIVNNWVDNQTRGKIKDLVSSNDMSKMELIV 166
            ::|.:.|.|:..:.:.:....|::|. .|..|:...:|.||::|::||||:|.....:....::|
  Rat   140 QEFPICPEYSDDITEFYHTTIESVDFQKDTEKSREEINFWVESQSQGKIKELFDKEAIDNSTVLV 204

  Fly   167 L-NAIYFKGQWEYKFNPKLTKKRNFRVSDQKSVPVEMMSLFQSFRAAHDSELGAKIIELPYRNSS 230
            | ||:|||.:||.:|:.:.|....|.:|:.:...|:||:....||.....||.|:|:|:.|....
  Rat   205 LVNAVYFKAKWEKEFDSENTVDAPFCLSENEKKTVKMMNQKGQFRIGFIEELQAQILEMKYTTGK 269

  Fly   231 LSMLIFLP----DQVDGLSELEKKIVGFK-------PKLSKMDVTLRLPKFKIEFFAQLNKVLVA 284
            ||||:.||    |.|..|.||||||...|       ..:|:..|.:..|:|.:|....||.||..
  Rat   270 LSMLVLLPSSSEDNVKSLQELEKKINHEKLLAWSNPENMSEKPVAISFPQFIMEDSYDLNSVLQD 334

  Fly   285 MGIQDAFE-KSADFKDLVENSNVHVKKVIHKAFIEVNEEGAEAAAATALLFVRYSMPMPSSQMVF 348
            |||:|.|: ..||...:.::.::|:.||:||.|:||:|.|.:||||:..:....::|   |::.|
  Rat   335 MGIRDVFDGTKADLTGISKSPSLHLSKVVHKTFVEVDEMGTQAAAASGAVVAEKALP---SRVEF 396

  Fly   349 NADHPFAYVIRDR--ETIYFQGHFVKP 373
            ||:.||.:.||..  :::.|.|....|
  Rat   397 NANRPFLFFIRHNGTQSLLFCGRVYSP 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	SERPIN	14..370	CDD:238101	133/412 (32%)
Serpinb12	XP_038946584.1	serpinB12_yukopin	1..423	CDD:381037	133/415 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.930