DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28F and Serpinh1

DIOPT Version :9

Sequence 1:	NP_524957.2	Gene:	Spn28F / 49807	FlyBaseID:	FBgn0028987	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_058869.2	Gene:	Serpinh1 / 29345	RGDID:	69302	Length:	417	Species:	Rattus norvegicus

Alignment Length:	409	Identity:	108/409 - (26%)
Similarity:	182/409 - (44%)	Gaps:	48/409 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LCLLLLATSV---------------------------SCRFADDFYQLLAKENAANNLISSPLSV 41
            ||||.:|.:.                           |...|...||.:||:.|..|::.|||.|
  Rat     9 LCLLAVALAAEVKKPVEATAPGTAEKLSSKATTLAERSTGLAFSLYQAMAKDQAVENILLSPLVV 73

  Fly    42 EIALSMAYMGARAKTAQEMRNVL---KLPDDKKEVAAKYKDLLSKL-EGREKVATLSLANRIYVN 102
            ..:|.:..:|.:|.||.:.:.||   ||.|:  ||.....:||..| ....:..|..|.:|:|..
  Rat    74 ASSLGLVSLGGKATTASQAKAVLSAEKLRDE--EVHTGLGELLRSLSNSTARNVTWKLGSRLYGP 136

  Fly   103 KKFQLVPSYNQMVKDSFMAEAEAIDIVDPNKASSIVNNWVDNQTRGKIKDLVSSNDMSKMELIVL 167
            ........:.:..|..:..|...|:..|...|...:|.|....|.||:.::....:.:...|:|
  Rat   137 SSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWASQTTDGKLPEVTKDVERTDGALLV- 200

  Fly   168 NAIYFKGQWEYKFNPKLTKKRNFRVSDQKSVPVEMMSLFQSFRAAHDSELGAKIIELPYRNSSLS 232
            ||::||..|:.||:.|:...|.|.|:...:|.|.||.....:....|.:...:::|:|..:...|
  Rat   201 NAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEKLQLVEMPLAHKLSS 265

  Fly   233 MLIFLPDQVDGLSELEK-----KIVGFKPKLSKMDVTLRLPKFKIEFFAQLNKVLVAMGIQDAFE 292
            ::|.:|..|:.|..|||     ::..:..|:.|..|.:.|||..:|....|.|.|..:|:.:|.:
  Rat   266 LIILMPHHVEPLERLEKLLTKEQLKTWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAID 330

  Fly   293 KS-ADFKDLVENSNVHVKKVIHKAFIEVNEEGAEAAAATALLFVRYSMPMPSSQMVFNADHPFAY 356
            |: ||...:....::::..|.|....|.:.||......   ::.|..:..|.   :|.|||||.:
  Rat   331 KNKADLSRMSGKKDLYLASVFHATAFEWDTEGNPFDQD---IYGREELRSPK---LFYADHPFIF 389

  Fly   357 VIRDRE--TIYFQGHFVKP 373
            ::||.:  ::.|.|..|:|
  Rat   390 LVRDNQSGSLLFIGRLVRP 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	SERPIN	14..370	CDD:238101	101/367 (28%)
Serpinh1	NP_058869.2	serpinH1_CBP1	35..416	CDD:381003	103/383 (27%)
Serpinh1	NP_058869.2	Prevents secretion from ER. /evidence=ECO:0000305	414..417
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010