DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28F and Serpinb1a

DIOPT Version :9

Sequence 1:	NP_524957.2	Gene:	Spn28F / 49807	FlyBaseID:	FBgn0028987	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_001026812.1	Gene:	Serpinb1a / 291091	RGDID:	1306203	Length:	379	Species:	Rattus norvegicus

Alignment Length:	379	Identity:	127/379 - (33%)
Similarity:	211/379 - (55%)	Gaps:	20/379 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TSVSCRFADDFYQLLAKENAANNLISSPLSVEIALSMAYMGARAKTAQEMRNVLKLPDDKKEVAA 75
            :|.:..||.:.:..|::.:...|:..||.|:..||:|.::|.:..||.::...... |..::|.:
  Rat     5 SSANSLFALELFHTLSESSPTGNIFFSPFSISSALAMVFLGTKGTTAAQLSKTFHF-DSVEDVHS 68

  Fly    76 KYKDLLSKLEGREKVATLSLANRIYVNKKFQLVPSYNQMVKDSFMAEAEAIDIVDPNK-ASSIVN 139
            :::.|.:::..|....||.||||:|..|.:..:|.:....:..:.|:...:|....:: |...:|
  Rat    69 RFQSLNAEVSKRGASHTLKLANRLYGEKTYNFLPEFLTSTQKMYGADLAPVDFQHASEDARKEIN 133

  Fly   140 NWVDNQTRGKIKDLVSSNDMSKM-ELIVLNAIYFKGQWEYKFNPKLTKKRNFRVSDQKSVPVEMM 203
            .||..||.|||.:|::...:..| :|:::|||||||.||.||..:.|....||::.:.:..|:||
  Rat   134 QWVKGQTEGKIPELLAVGVVDSMTKLVLVNAIYFKGMWEEKFMKQDTTDAPFRLNKKNTKSVKMM 198

  Fly   204 SLFQSFRAAHDSELGAKIIELPYRNSSLSMLIFLPDQVD----GLSELEKKIVGFK-------PK 257
            ...:.|...:.|:|..|::|:||:...|||:|.||:.::    ||.::|::|...|       ..
  Rat   199 YQKKKFFFGYISDLKCKVLEMPYQGGELSMVILLPEDIEDESTGLKKIEEQITLEKLREWTKREN 263

  Fly   258 LSKMDVTLRLPKFKIEFFAQLNKVLVAMGIQDAFEKS-ADFKDLVENSNVHVKKVIHKAFIEVNE 321
            |..:||.::||:||||....||..|..:|:||.|..| ||...:..:.::.:.|::||||:||||
  Rat   264 LENIDVHVKLPRFKIEESYILNSNLGRLGLQDLFNSSKADLSGMSGSRDLFISKIVHKAFVEVNE 328

  Fly   322 EGAEAAAATALLFVRYSMPMPSSQMVFNADHPFAYVIRDRET--IYFQGHFVKP 373
            ||.|||||||.: ..:.|.:|..:  |.|||||.:.||...|  :.|.|....|
  Rat   329 EGTEAAAATAGI-ATFCMLLPEEE--FTADHPFIFFIRHNPTANVLFLGRVCSP 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	SERPIN	14..370	CDD:238101	125/371 (34%)
Serpinb1a	NP_001026812.1	SERPIN	4..379	CDD:294093	126/377 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.930