DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28F and Serpina3b

DIOPT Version :9

Sequence 1:	NP_524957.2	Gene:	Spn28F / 49807	FlyBaseID:	FBgn0028987	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_766612.1	Gene:	Serpina3b / 271047	MGIID:	2182835	Length:	420	Species:	Mus musculus

Alignment Length:	390	Identity:	111/390 - (28%)
Similarity:	189/390 - (48%)	Gaps:	26/390 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KHLCLLLLATSVSCRFADDFYQLLAKENAANNLISSPLSVEIALSMAYMGARAKTAQEMRNVLKL 66
            |.|..|.|| |::..||..||:.||.:|...|:..||..:..||:...:||:..|.:|:..|||.
Mouse    40 KQLDSLTLA-SINTDFAFSFYKELALKNPHKNIAFSPFGIATALNSLTLGAKGNTLEEILEVLKF 103

  Fly    67 ---PDDKKEVAAKYKDLLSKLEGREKVATLSLANRIYVNKKFQLVPSYNQMVKDSFMAEAEAIDI 128
               ...:.::...:|.||.:|........:...|.::|.|..|::..:.:..:..:..|....:.
Mouse   104 NLTETSEADIHQGFKHLLQRLSHPGDQVQIRTGNALFVEKHLQILAEFKEKARALYHTEVFTANF 168

  Fly   129 VDPNKASSIVNNWVDNQTRGKIKDLVSSNDMSKMELIVLNAIYFKGQWEYKFNPKLTKKRNFRVS 193
            ..|::|..::|:::.|||:||||:|||..| ....::::|.::||.:|...||...|....|.|.
Mouse   169 QQPHEAMKLINSYMSNQTQGKIKELVSDMD-GNTSMVIVNDLFFKAEWMVPFNSDDTFMGKFIVD 232

  Fly   194 DQKSVPVEMMSLFQSFRAAH--DSELGAKIIELPYRNSSLSMLIFLPD-----QVDGLSE---LE 248
            ..:.|.|.||.. ::.|..:  |.||...::||.|:.:..:|.| |||     ||:...:   |:
Mouse   233 RSRHVKVPMMKT-KNLRTPYFRDEELKCTVVELNYKGNGKAMFI-LPDQGKMQQVEASLQPGTLK 295

  Fly   249 KKIVGFKPKLSKMDVTLRLPKFKIEFFAQLNKVLVAMGIQDAFEKSADFKDLVENSNVHVKKVIH 313
            |.....:|:..|   .|.||||.:.....|..:|..:||::.|...||...:....|:.|.::||
Mouse   296 KWRKSLRPRKIK---ELHLPKFSLSQHYNLEDILPELGIRELFSTQADLSGITGVKNITVSEMIH 357

  Fly   314 KAFIEVNEEGAEAAAATALLFVRYSMPMPSSQMVF-NADHPFAYVIRDRET--IYFQGHFVKPNE 375
            ...:::.|:|.|..|.|   .|.|:......:.|| ..:..|.|::.|:..  |:..|..:.|:|
Mouse   358 STELDMTEKGTEGDAIT---IVGYNFMSAKLKPVFVKFEDQFLYIVLDQGDLWIHVMGKVINPSE 419

Fly 376 375
Mouse 420 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	SERPIN	14..370	CDD:238101	103/371 (28%)
Serpina3b	NP_766612.1	SERPIN	51..414	CDD:294093	103/371 (28%)
Serpina3b	NP_766612.1	RCL	367..392		8/27 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010