DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28F and Serpinb13

DIOPT Version :9

Sequence 1:	NP_524957.2	Gene:	Spn28F / 49807	FlyBaseID:	FBgn0028987	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_766440.2	Gene:	Serpinb13 / 241196	MGIID:	3042250	Length:	389	Species:	Mus musculus

Alignment Length:	388	Identity:	119/388 - (30%)
Similarity:	208/388 - (53%)	Gaps:	30/388 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SVSCRFADDFYQLLAKENAANNLISSPLSVEIALSMAYMGARAKTAQEMRNVL---------KLP 67
            :.:.:|..|.::.|.|.| ..|:..||:.:..|:.|..:|.|..||.|::.||         ::.
Mouse     6 TAATQFLFDLFKELNKTN-DGNVFFSPVGISTAIGMIILGTRGATASELQKVLYTEQGTESSRIK 69

  Fly    68 DDKKEVAAK------YKDLLSKLEGREKVATLSLANRIYVNKKFQLVPSYNQMVKDSFMAEAEAI 126
            .:::|:..:      .:.||:::........|.::||::..|.:..:..|...|:..:.|..|.:
Mouse    70 SEEEEIEKREEIHHQLQMLLTEISKFSNDYDLIISNRLFGEKTYLFLQKYIDYVEKYYHASLEPV 134

  Fly   127 DIVD-PNKASSIVNNWVDNQTRGKIKDLVSSNDM-SKMELIVLNAIYFKGQWEYKFNPKLTKKRN 189
            |.|: .:::...:|:||::||..|:|||.....: |..:|:::|.:||||.|:.:|..:.||:.:
Mouse   135 DFVNAADESRKKINSWVESQTNVKVKDLFPEGSLNSSTKLVLINTVYFKGLWDREFKKEHTKEED 199

  Fly   190 FRVSDQKSVPVEMMSLFQSFRAAHDSELGAKIIELPYRNSSLSMLIFLPDQVDGLSEL------E 248
            |.::...|.||:||:|..||......:|.|||:.:||:|:.:||.:.||:.:|||.::      |
Mouse   200 FWLNKNLSKPVQMMALCSSFNFTFLEDLQAKIVGIPYKNNDISMFVLLPNDIDGLEKIMDKMSPE 264

  Fly   249 KKIVGFKP-KLSKMDVTLRLPKFKIEFFAQLNKVLVAMGIQDAFEKSADFKDLVENSNVHVKKVI 312
            |.:....| .|.:..|.||||:.::|....|..||.|:||..||.:.||:..:...|.:|.:..:
Mouse   265 KLVEWTSPGHLEQRRVDLRLPRLQVEETYDLEPVLEAVGIHSAFSEHADYSGMSARSGLHAQNFL 329

  Fly   313 HKAFIEVNEEGAEAAAATALLFVRYSMPMPSSQMVFNADHPFAYVIRDRE--TIYFQGHFVKP 373
            |::|:.|.|||.||.|.|.   |...:...:|..:.:.:|||.:.||.||  :|.|.|.|..|
Mouse   330 HRSFLVVTEEGVEATAGTG---VGLKVSSAASCELVHCNHPFLFFIRHRESDSILFFGKFSSP 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	SERPIN	14..370	CDD:238101	117/381 (31%)
Serpinb13	NP_766440.2	SERPIN	4..389	CDD:294093	118/386 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	216	1.000	Domainoid score	I2692
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	217	1.000	Inparanoid score	I3582
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.970