DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28F and Serpina1a

DIOPT Version :9

Sequence 1:	NP_524957.2	Gene:	Spn28F / 49807	FlyBaseID:	FBgn0028987	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_001239498.1	Gene:	Serpina1a / 20700	MGIID:	891971	Length:	436	Species:	Mus musculus

Alignment Length:	379	Identity:	103/379 - (27%)
Similarity:	187/379 - (49%)	Gaps:	26/379 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LATSVSCRFADDFYQLLAKENAANNLISSPLSVEIALSMAYMGARAKTAQEMRNVLKL---PDDK 70
            :||::. .||...|:.|..::..:|:..||:|:..|.:|..:|::..|..::...|:.   ...:
Mouse    67 IATNLG-DFAISLYRELVHQSNTSNIFFSPVSIATAFAMLSLGSKGDTHTQILEGLQFNLTQTSE 130

  Fly    71 KEVAAKYKDLLSKLEGREKVATLSLANRIYVNKKFQLVPSYNQMVKDSFMAEAEAIDIVDPNKAS 135
            .::...::.||..|...:....||..|.::||...:||..:.:..|:.:.||..:::..:..:|.
Mouse   131 ADIHKSFQHLLQTLNRPDSELQLSTGNGLFVNNDLKLVEKFLEEAKNHYQAEVFSVNFAESEEAK 195

  Fly   136 SIVNNWVDNQTRGKIKDLVSSNDMSKMELIVLNAIYFKGQWEYKFNPKLTKKRNFRVSDQKSVPV 200
            .::|::|:..|:|||.:.|...|...: ..:.|.|.|||:|:..|:|:.|::..|.|.:..:|.|
Mouse   196 KVINDFVEKGTQGKIAEAVKKLDQDTV-FALANYILFKGKWKKPFDPENTEEAEFHVDESTTVKV 259

  Fly   201 EMMSLFQSFRAAHDSELGAKIIELPYRNSSLSMLIFLPDQVDG-LSELEKKIVGFKPKLSKMDVT 264
            .||:|.......|.|.|.:.::.:.|..::.::.: |||  || :..||:.:  .|..:||..:.
Mouse   260 PMMTLSGMLHVHHCSTLSSWVLLMDYAGNATAVFL-LPD--DGKMQHLEQTL--SKELISKFLLN 319

  Fly   265 LR-------LPKFKIEFFAQLNKVLVAMGIQDAFEKSADFKDLV-ENSNVHVKKVIHKAFIEVNE 321
            .|       .|:..|.....|..::..:||...|...||...:. ||:.:.:.:.:|||.:.::|
Mouse   320 RRRRLAQIHFPRLSISGEYNLKTLMSPLGITRIFNNGADLSGITEENAPLKLSQAVHKAVLTIDE 384

  Fly   322 EGAEAAAATALLFVRYSMPMPSSQMVFNADHPFAYVIRDRET--IYFQGHFVKP 373
            .|.||||.|.|..|..|||     .:...||||.::|.:..|  ..|.|..|.|
Mouse   385 TGTEAAAVTVLQMVPMSMP-----PILRFDHPFLFIIFEEHTQSPIFLGKVVDP 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	SERPIN	14..370	CDD:238101	99/369 (27%)
Serpina1a	NP_001239498.1	SERPIN	76..433	CDD:214513	98/367 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010