DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28F and Serpinf1

DIOPT Version :9

Sequence 1:	NP_524957.2	Gene:	Spn28F / 49807	FlyBaseID:	FBgn0028987	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_035470.3	Gene:	Serpinf1 / 20317	MGIID:	108080	Length:	417	Species:	Mus musculus

Alignment Length:	388	Identity:	124/388 - (31%)
Similarity:	194/388 - (50%)	Gaps:	47/388 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LATSVSCRFADDFYQLLAKENAANNLISSPLSVEIALSMAYMGARAKTAQEMRNVLKL-----PD 68
            ||.:|| .|..|.|:|.:..:...|::.|||||..|||...:||..:|...:...|..     ||
Mouse    53 LAAAVS-NFGYDLYRLRSSASPTGNVLLSPLSVATALSALSLGAEHRTESVIHRALYYDLITNPD 116

  Fly    69 DKKEVAAKYKDLLSKLEGREKVATLSLANRIYVNKKFQLVPSYNQMVKDSFMAEAE-------AI 126
                :.:.||:||:.:...||  .|..|:||...:|.:        ||.||:|..|       .|
Mouse   117 ----IHSTYKELLASVTAPEK--NLKSASRIVFERKLR--------VKSSFVAPLEKSYGTRPRI 167

  Fly   127 DIVDPNKASSIVNNWVDNQTRGKIKDLVSSNDM-SKMELIVLNAIYFKGQWEYKFNPKLTKKRNF 190
            ...:|......:||||..|.:|||..  |:.:| |.:.:::|...||||||..||:.:.|..::|
Mouse   168 LTGNPRVDLQEINNWVQAQMKGKIAR--STREMPSALSILLLGVAYFKGQWVTKFDSRKTTLQDF 230

  Fly   191 RVSDQKSVPVEMMSLFQS-FRAAHDSELGAKIIELPYRNSSLSMLIFLPDQV-DGLSELEKKIVG 253
            .:.:.::|.|.|||..:: .|...||:|..||.:||. ..|:|::.|||..| ..|:.:|:.:..
Mouse   231 HLDEDRTVRVPMMSDPKAILRYGLDSDLNCKIAQLPL-TGSMSIIFFLPLTVTQNLTMIEESLTS 294

  Fly   254 -----FKPKLSKMDVTLRLPKFKIEFFAQLNKVLVAMGIQDAFEKSADFKDLVENSNVHVKKVIH 313
                 ...:|..:...|.:||.|:.|..:|.|.|..|.:|..|| |.||.. :....|.:.:|.|
Mouse   295 EFIHDIDRELKTIQAVLTVPKLKLSFEGELTKSLQDMKLQSLFE-SPDFSK-ITGKPVKLTQVEH 357

  Fly   314 KAFIEVNEEGAEAAAATALLFVRYSMPMPSSQMVFNADHPFAYVIRDRET--IYFQGHFVKPN 374
            :|..|.|||||.::.:..|..||.:.|:.     ::.:.||.:|:||.:|  :.|.|..:.|:
Mouse   358 RAAFEWNEEGAGSSPSPGLQPVRLTFPLD-----YHLNQPFLFVLRDTDTGALLFIGRILDPS 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	SERPIN	14..370	CDD:238101	120/377 (32%)
Serpinf1	NP_035470.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	17..41
Serpinf1	NP_035470.3	PEDF	39..414	CDD:239007	123/385 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010