Protein Alignment Spn28F and SERPINB1

DIOPT Version :10

• Sequence 1: NP_524957.2
• Gene: Spn28F / 49807
• FlyBaseID: FBgn0028987
• Length: 375
• Species: Drosophila melanogaster
• Sequence 2: NP_109591.1
• Gene: SERPINB1 / 1992
• HGNCID: 3311
• Length: 379
• Species: Homo sapiens
• Alignment Length: 379
• Identity: 129/379 - (34%)
• Similarity: 212/379 - (55%)
• Gaps: 20/379 - (5%)

  Fly    11 TSVSCRFADDFYQLLAKENAANNLISSPLSVEIALSMAYMGARAKTAQEMRNVLKLPDDKKEVAA 75
            :|.:.|||.|.:..|::.|.|.|:..||.|:..|::|.::|.|..||.::...... :..:||.:
Human     5 SSANTRFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKTFHF-NTVEEVHS 68

  Fly    76 KYKDLLSKLEGREKVATLSLANRIYVNKKFQLVPSYNQMVKDSFMAEAEAIDIVDPNK-ASSIVN 139
            :::.|.:.:..|.....|.||||:|..|.:..:|.:....:.::.|:..::|....:: |...:|
Human    69 RFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVDFQHASEDARKTIN 133

  Fly   140 NWVDNQTRGKIKDLVSSNDMSKM-ELIVLNAIYFKGQWEYKFNPKLTKKRNFRVSDQKSVPVEMM 203
            .||..||.|||.:|::|..:..| :|:::|||||||.|:.||..:.|....||::.:....|:||
Human   134 QWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRLNKKDRKTVKMM 198

  Fly   204 SLFQSFRAAHDSELGAKIIELPYRNSSLSMLIFLPDQVD----GLSELEKKIV------GFKPK- 257
            ...:.|...:..:|..:::||||:...|||:|.|||.::    ||.::|:::.      ..||:
Human   199 YQKKKFAYGYIEDLKCRVLELPYQGEELSMVILLPDDIEDESTGLKKIEEQLTLEKLHEWTKPEN 263

  Fly   258 LSKMDVTLRLPKFKIEFFAQLNKVLVAMGIQDAFEKS-ADFKDLVENSNVHVKKVIHKAFIEVNE 321
            |..::|.:.||:||:|....||..|..:|:||.|..| ||...:....::.:.|::||:|:||||
Human   264 LDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFNSSKADLSGMSGARDIFISKIVHKSFVEVNE 328

  Fly   322 EGAEAAAATALLFVRYSMPMPSSQMVFNADHPFAYVIRDRE--TIYFQGHFVKP 373
            ||.|||||||.: ..:.|.||...  |.|||||.:.||...  :|.|.|.|..|
Human   329 EGTEAAAATAGI-ATFCMLMPEEN--FTADHPFLFFIRHNSSGSILFLGRFSSP 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	serpin42Dd-like_insects	12..373	CDD:381070	128/376 (34%)
SERPINB1	NP_109591.1	serpinB1_LEI	1..379	CDD:381028	128/377 (34%)
		CARD-binding motif (CBM). /evidence=ECO:0000269|PubMed:30692621	351..379		12/29 (41%)