DRSC/TRiP Functional Genomics Resources

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Protein Alignment Spn28F and Serpind1

DIOPT Version :9

Sequence 1:NP_524957.2 Gene:Spn28F / 49807 FlyBaseID:FBgn0028987 Length:375 Species:Drosophila melanogaster
Sequence 2:NP_001317976.1 Gene:Serpind1 / 15160 MGIID:96051 Length:478 Species:Mus musculus


Alignment Length:378 Identity:116/378 - (30%)
Similarity:202/378 - (53%) Gaps:27/378 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 VSCRFADDFYQLLAKENA--ANNLISSPLSVEIALSMAYMGARAKTAQEMRNVLKLPD-----DK 70
            ::.:||.:.|::| |:.|  ::||..:|:.:..|:.|..:|.|.:|.:|:.:||...|     .|
Mouse   108 LNAKFAFNLYRVL-KDQATTSDNLFIAPVGISTAMGMISLGLRGETHEEVHSVLHFRDFVNASSK 171

  Fly    71 KEVAA---KYKDLLSKLEGREKVATLSLANRIYVNKKFQLVPSYNQMVKDSFMAEAEAIDIVDPN 132
            .||..   .::.|..:|..|....||...|.:|:.|:|.:...:...:::.:.|||:..:..||.
Mouse   172 YEVTTIHNLFRKLTHRLFRRNFGYTLRSVNGLYIQKQFPIREDFKAAMREFYFAEAQEANFPDPA 236

  Fly   133 KASSIVNNWVDNQTRGKIKDLVSSNDMSKMELIVLNAIYFKGQWEYKFNPKLTKKRNFRVSDQKS 197
            ..|. .||.:...|:|.||:.:.:.|.: .::::||.|||||.|..||..::|...|||:::::.
Mouse   237 FISK-ANNHILKLTKGLIKEALENIDPA-TQMLILNCIYFKGTWVNKFPVEMTHNHNFRLNEREV 299

  Fly   198 VPVEMMSLFQSFRAAHDSELGAKIIELPYRNSSLSMLIFLPDQVDGLSELEKKIV-----GFKPK 257
            |.|.||....:|.||:|.||...|::|.| ...:||||.:|.::.|:..||.::.     .::..
Mouse   300 VKVSMMQTKGNFLAANDQELDCDILQLEY-VGGISMLIVVPRKLSGMKTLEAQLTPQVVERWQKS 363

  Fly   258 LSKMDVTLRLPKFKIEFFAQLNKVLVAMGIQDAFEKSADFKDLVENSNVHVKKVIHKAFIEVNEE 322
            ::.....:.|||||:|....|.:||.:|||...|.|:.:... :.:..:.:....|::.|.||||
Mouse   364 MTNRTREVLLPKFKLEKNYNLVEVLKSMGITKLFNKNGNMSG-ISDQRIAIDLFKHQSTITVNEE 427

  Fly   323 GAEAAAATALLFVRYSMPMPSSQMVFNADHPFAYVIRDRET--IYFQGHFVKP 373
            |.:|||.|.:.|    ||: |:|:.|..|.||.:::.:..|  :.|.|....|
Mouse   428 GTQAAAVTTVGF----MPL-STQVRFTVDRPFLFLVYEHRTSCLLFMGKVTNP 475

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Spn28FNP_524957.2 SERPIN 14..370 CDD:238101 115/372 (31%)
Serpind1NP_001317976.1 HCII 43..476 CDD:239002 116/378 (31%)
2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like) 54..78
Glycosaminoglycan-binding site. /evidence=ECO:0000250 171..191 5/19 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D556621at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11461
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
33.020

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