DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn38F and SERPINH1

DIOPT Version :9

Sequence 1:	NP_524956.2	Gene:	Spn38F / 49806	FlyBaseID:	FBgn0028986	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_001193943.1	Gene:	SERPINH1 / 871	HGNCID:	1546	Length:	418	Species:	Homo sapiens

Alignment Length:	367	Identity:	94/367 - (25%)
Similarity:	177/367 - (48%)	Gaps:	26/367 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LYQLLAKENADKNLITSPLSVEIALSLAYMGARGKTAQEMRDVL---KLPDDKKEVAAKFKDLLS 82
            |||.:||:.|.:|::.||:.|..:|.|..:|.:..||.:.:.||   :|.|:  ||.|...:||.
Human    54 LYQAMAKDQAVENILVSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDE--EVHAGLGELLR 116

  Fly    83 KLEGRESVAIL-SLANRIYVNNKFKLVPEYNQMVKDSFKAEAEAISANNPKITASIVNKWVDTQT 146
            .|....:..:. .|.:|:|..:......::.:..|..:..|...|:..:.:.....:|:|....|
Human   117 SLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTT 181

  Fly   147 SGKIRDL---VMPSDVANLVLVILNAIYFKGQWQKKFNTEQTKS-DFHISDQKSVPVQMMSLVRP 207
            .||:.::   |..:|.|.||    ||::||..|.:||:.:...: .|.::...:|.|.||.....
Human   182 DGKLPEVTKDVERTDGALLV----NAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVMMMHRTGL 242

  Fly   208 FGVSYDRELGANVIELPYRNSNLSMVIFLPDKVDGLPELEKKMVG-----FTPKLININVHLRLP 267
            :....|.:....::|:|..:...|::|.:|..|:.|..|||.:..     :..|:....|.:.||
Human   243 YNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKKAVAISLP 307

  Fly   268 KFKIEFSARLEQVLIAMGIQDAF-KTSADFNDLVANSGAHVGGVVHKAFLEVNEEGSEAAAATAV 331
            |..:|.:..|::.|..:|:.:|. |..||.:.:......::..|.|....|::.:|:   .....
Human   308 KGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFELDTDGN---PFDQD 369

  Fly   332 VFRYKSIRSPPMDFNVNHPFAYVIRDAE--NIYFQGHFVNPE 371
            ::..:.:|||.: |..:|||.:::||.:  ::.|.|..|.|:
Human   370 IYGREELRSPKL-FYADHPFIFLVRDTQSGSLLFIGRLVRPK 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn38F	NP_524956.2	Serpin	14..370	CDD:278507	93/364 (26%)
SERPINH1	NP_001193943.1	serpinH1_CBP1	36..417	CDD:381003	94/367 (26%)
SERPINH1	NP_001193943.1	Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	415..418
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920