DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn38F and SERPINA6

DIOPT Version :9

Sequence 1:	NP_524956.2	Gene:	Spn38F / 49806	FlyBaseID:	FBgn0028986	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_001747.3	Gene:	SERPINA6 / 866	HGNCID:	1540	Length:	405	Species:	Homo sapiens

Alignment Length:	406	Identity:	105/406 - (25%)
Similarity:	186/406 - (45%)	Gaps:	45/406 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YLCLLLLAT--------------------------SVSCRFTDDLYQLLAKENADKNLITSPLSV 41
            |.|||.|.|                          |.:..|...||:.|...:..||:..||:|:
Human     6 YTCLLWLPTSGLWTVQAMDPNAAYVNMSNHHRGLASANVDFAFSLYKHLVALSPKKNIFISPVSI 70

  Fly    42 EIALSLAYMGARGKTAQEMRDVL--KLPD-DKKEVAAKFKDLLSKLEGRESVAILSLANRIYVNN 103
            .:||::..:|..|.|..::...|  .|.: .:.|:...|:.|.......::...:::.|.::::.
Human    71 SMALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKSDTSLEMTMGNALFLDG 135

  Fly   104 KFKLVPEYNQMVKDSFKAEAEAISANNPKITASIVNKWVDTQTSGKIRDLVMPSDVANLVLVILN 168
            ..:|:..::..:|..:::|..|::..:....:..:|.:|..:|.|||.||....| :..:||::|
Human   136 SLELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQGKIVDLFSGLD-SPAILVLVN 199

  Fly   169 AIYFKGQWQKKFNTEQTKSD-FHISDQKSVPVQMMSLVRPFGVSYDRELGANVIELPYRNSNLSM 232
            .|:|||.|.:.|:...|:.: |::.:...|.|.||.........:|.||...::::.| ..|.::
Human   200 YIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQMNY-VGNGTV 263

  Fly   233 VIFLPDKVDG-----LPELEKKMVG-FTPKLININVHLRLPKFKIEFSARLEQVLIAMGIQDAFK 291
            ...||||  |     :..|.:..:. ::..|.:..|.|.:||..|.....|..||..|||.|.|.
Human   264 FFILPDK--GKMNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFT 326

  Fly   292 TSADFNDLVANSGAHVGGVVHKAFLEVNEEGSEAAAATAVVFRYKSIRSPPMDFNVNHPFAYVIR 356
            ..|:|:.:..::......|||||.|::||||.:.|.:|.|..   ::.|.|:....|.||..:|.
Human   327 NQANFSRITQDAQLKSSKVVHKAVLQLNEEGVDTAGSTGVTL---NLTSKPIILRFNQPFIIMIF 388

  Fly   357 D--AENIYFQGHFVNP 370
            |  ..:..|....:||
Human   389 DHFTWSSLFLARVMNP 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn38F	NP_524956.2	Serpin	14..370	CDD:278507	96/367 (26%)
SERPINA6	NP_001747.3	alpha-1-antitrypsin_like	42..401	CDD:239011	96/365 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020