DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn38F and Serpind1

DIOPT Version :9

Sequence 1:	NP_524956.2	Gene:	Spn38F / 49806	FlyBaseID:	FBgn0028986	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_077358.1	Gene:	Serpind1 / 79224	RGDID:	619854	Length:	479	Species:	Rattus norvegicus

Alignment Length:	388	Identity:	108/388 - (27%)
Similarity:	192/388 - (49%)	Gaps:	50/388 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VSCRFTDDLYQLLAKE-NADKNLITSPLSVEIALSLAYMGARGKTAQEMRDVLKLPD-----DKK 71
            ::.:|..:||::|..: .:..|:..:|:.:..|:.:..:|.||:|.:|:..||...|     .|.
  Rat   109 LNAKFAFNLYRVLKDQATSSDNIFIAPVGISTAMGMISLGLRGETHEEVHSVLHFKDFVNASSKY 173

  Fly    72 EVAA---KFKDLLSKLEGRESVAILSLANRIYVNNKFKLVPEYNQMVKDSFKAEAEAISANNPKI 133
            ||..   .|:.|..:|..|.....|...|.:|:..:|.:..::...:::.:.|||:....::|..
  Rat   174 EVTTIHNLFRKLTHRLFRRNFGYTLQSVNDLYIQKQFPIREDFKAAMREFYFAEAQEADFSDPAF 238

  Fly   134 TASIVNKWVDTQTSGKIRDLVMPSDVANLVLVILNAIYFKGQWQKKFNTEQTKS-DFHISDQKSV 197
             .|..|..:...|.|.|::.:..:|.|. .::|||.|||||.|..||..|.|.: :|.:::::.|
  Rat   239 -ISKANSHILKLTKGLIKEALENTDSAT-QMMILNCIYFKGAWMNKFPVEMTHNHNFRLNEREVV 301

  Fly   198 PVQMMSLVRPFGVSYDRELGANVIELPYRNSNLSMVIFLPDKVDGLPELEKKMVGFTPKLI---- 258
            .|.||.....|..:.|:||..::::|.| ...:||:|.:|.|:.|:..||.::   ||:::
  Rat   302 KVSMMQTKGNFLAANDQELDCDILQLEY-VGGISMLIVIPRKLSGMKTLEAQL---TPQVVERWQ 362

  Fly   259 ----NINVHLRLPKFKIEFSARLEQVLIAMGIQDAFKTSADFNDLVANSGAHVGGV--------- 310
                |....:.|||||:|.:..|.:||.:|||...|           |...::.|:
  Rat   363 KSMTNRTREVLLPKFKLEKNYNLVEVLKSMGITKLF-----------NKNGNMSGISDQRIIIDL 416

  Fly   311 -VHKAFLEVNEEGSEAAAATAVVFRYKSIRSPPMDFNVNHPFAYVIRDAEN--IYFQGHFVNP 370
             .|::.:.|||||::|||.|.|.|...|.:   :.|.|:.||.:::.:...  :.|.|...||
  Rat   417 FKHQSTITVNEEGTQAAAVTTVGFMPLSTQ---VRFTVDRPFLFLVYEHRTSCLLFMGRVANP 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn38F	NP_524956.2	Serpin	14..370	CDD:278507	106/385 (28%)
Serpind1	NP_077358.1	HCII	44..477	CDD:239002	108/388 (28%)
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	55..79
		Glycosaminoglycan-binding site. /evidence=ECO:0000250	172..192		6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020