DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn38F and SERPINB4

DIOPT Version :9

Sequence 1:	NP_524956.2	Gene:	Spn38F / 49806	FlyBaseID:	FBgn0028986	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_002965.1	Gene:	SERPINB4 / 6318	HGNCID:	10570	Length:	390	Species:	Homo sapiens

Alignment Length:	389	Identity:	134/389 - (34%)
Similarity:	212/389 - (54%)	Gaps:	32/389 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TSVSCRFTDDLYQLLAKENADKNLITSPLSVEIALSLAYMGARGKTAQEMRDVL---KLPDDKKE 72
            :..:.:|..||:|...| :.:.|:..||:|:..||.:..:||:..|||::..||   ::.::..|
Human     5 SEANTKFMFDLFQQFRK-SKENNIFYSPISITSALGMVLLGAKDNTAQQISKVLHFDQVTENTTE 68

  Fly    73 VAA------------KFKDLLSKLEGRESVAILSLANRIYVNNKFKLVPEYNQMVKDSFKAEAEA 125
            .||            :|:.||::.........|.:||:::....::.:.||...:|..::...|:
Human    69 KAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYQFLQEYLDAIKKFYQTSVES 133

  Fly   126 IS-ANNPKITASIVNKWVDTQTSGKIRDLVMPSDVAN-LVLVILNAIYFKGQWQKKFNTEQTKSD 188
            .. ||.|:.:...:|.||::||:.||::|.....:.| ..||::|||||||||:.||..|.||.:
Human   134 TDFANAPEESRKKINSWVESQTNEKIKNLFPDGTIGNDTTLVLVNAIYFKGQWENKFKKENTKEE 198

  Fly   189 -FHISDQKSVPVQMMSLVRPFGVSYDRELGANVIELPYRNSNLSMVIFLPDKVDGLPELEKKMVG 252
             |..:......||||.....|..:...::.|.|:|:||:..:|||::.||:::|||.:||:|:.
Human   199 KFWPNKNTYKSVQMMRQYNSFNFALLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQKLEEKLT- 262

  Fly   253 FTPKLI------NIN---VHLRLPKFKIEFSARLEQVLIAMGIQDAFKTSADFNDLVANSGAHVG 308
             ..||:      |:.   |.|.||:||:|.|..|:..|..||:.:.|...||.:.:..:.|..|.
Human   263 -AEKLMEWTSLQNMRETCVDLHLPRFKMEESYDLKDTLRTMGMVNIFNGDADLSGMTWSHGLSVS 326

  Fly   309 GVVHKAFLEVNEEGSEAAAATAVVFRYKSIRSPPMDFNVNHPFAYVIRD--AENIYFQGHFVNP 370
            .|:||||:||.|||.|||||||||....|..|...:|..||||.:.||.  ..:|.|.|.|.:|
Human   327 KVLHKAFVEVTEEGVEAAAATAVVVVELSSPSTNEEFCCNHPFLFFIRQNKTNSILFYGRFSSP 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn38F	NP_524956.2	Serpin	14..370	CDD:278507	133/384 (35%)
SERPINB4	NP_002965.1	SERPIN	4..390	CDD:320777	133/387 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	221	1.000	Domainoid score	I2614
eggNOG	1	0.900	-	-		E33208_3B998
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H76659
Inparanoid	1	1.050	222	1.000	Inparanoid score	I3541
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	1	1.000	-	-		mtm8652
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.780