DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn38F and Serpinb2

DIOPT Version :9

Sequence 1:	NP_524956.2	Gene:	Spn38F / 49806	FlyBaseID:	FBgn0028986	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_067728.1	Gene:	Serpinb2 / 60325	RGDID:	621823	Length:	416	Species:	Rattus norvegicus

Alignment Length:	419	Identity:	118/419 - (28%)
Similarity:	197/419 - (47%)	Gaps:	78/419 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FTDDLYQLLAKENADKNLITSPLSVEIALSLAYMGARGKTAQEMRDVLKL------------PDD 69
            |..:|.:.:.:.|:.:|:..||.|:...|::.::||:..|.::|..||..            |::
  Rat    11 FALNLLKQIEQSNSTQNIFISPWSISSTLAIVFLGAQANTEEQMAKVLNFDKIGSYDLTPGNPEN 75

  Fly    70 ------------------------KKEVAAKFKDLLSKLE-GRESVAILSLANRIYVNNKFKLVP 109
                                    :.::.:.|..|.|.:. .|....:|..||:::.....:...
  Rat    76 FHGCDFAQHIQRDNYPVAILQAQARDKIHSAFSSLSSTINTPRLGDYLLESANKLFGEKSARFKE 140

  Fly   110 EYNQMVKDSFKAEAEAIS----ANNPKITASIVNKWVDTQTSGKIRDLVMPSDV-ANLVLVILNA 169
            ||.|..|..:..|.||:.    ||..:   ..:|.||.|||.|:|.:|:....| .:..:|::|.
  Rat   141 EYIQRCKKYYSTEPEAVDFLECANEAR---KKINSWVKTQTKGEIPNLLPEGSVDEDTKMVLVNT 202

  Fly   170 IYFKGQW----QKKFNTEQTKSDFHISDQKSVPVQMMSLVRPFGVSYDRELGANVIELPYRNSNL 230
            |||||:|    ||:.|   ....|.::..:|.|||||.|.....:.|.::|...::|||| ..|:
  Rat   203 IYFKGRWKTPFQKRLN---GLYPFRVNLNESKPVQMMYLREKLNIGYIKDLKTQILELPY-IGNI 263

  Fly   231 SMVIFLPDKVD----GLPELEKKMVGFTPKLININ------------VHLRLPKFKIEFSARLEQ 279
            ||.:.|||:::    ||..||:: :.|.    |.|            |.:.:||||:..:..|:.
  Rat   264 SMFLLLPDEIEDSSTGLEMLERE-INFD----NFNKWISKETLDEDDVLVYIPKFKLAQNYELKP 323

  Fly   280 VLIAMGIQDAF-KTSADFNDLVANSGAHVGGVVHKAFLEVNEEGSEAAAATAVVFRYKSIRSPPM 343
            :|..||::||| |..|||:.:..::...:..|.|:|.::|||||:.||..|..|...::....|
  Rat   324 ILQRMGMEDAFNKGKADFSGMSESNDLFLSEVFHQATVDVNEEGTVAAGGTGAVMTGRTGHGGP- 387

  Fly   344 DFNVNHPFAYVIRD--AENIYFQGHFVNP 370
            .|..:|||.:.|.:  ...|.|.|.|.:|
  Rat   388 QFVADHPFLFFIMNNITRTILFVGRFSSP 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn38F	NP_524956.2	Serpin	14..370	CDD:278507	117/417 (28%)
Serpinb2	NP_067728.1	serpinB2_PAI-2	2..416	CDD:381029	117/417 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	1	1.000	-	-		otm46144
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.930