DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn38F and serpini1

DIOPT Version :9

Sequence 1:	NP_524956.2	Gene:	Spn38F / 49806	FlyBaseID:	FBgn0028986	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_001122164.1	Gene:	serpini1 / 557627	ZFINID:	ZDB-GENE-060503-390	Length:	415	Species:	Danio rerio

Alignment Length:	380	Identity:	115/380 - (30%)
Similarity:	192/380 - (50%)	Gaps:	21/380 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VSCRFTDDLYQLLAKENADKNLITSPLSVEIALSLAYMGARGKTAQEMRDVLKLPDDKK-EVAAK 76
            |:..|:..||..|...:.::|:|.|||||.:||.:..:||||.:.||:|..:.....:: |..:.
Zfish    27 VTAEFSVRLYHQLQISSGEENIIFSPLSVALALGMVELGARGSSLQEIRQAVGYSHFREDEEFSL 91

  Fly    77 FKDLLSKLEGRESVAILSLANRIYVNNKFKLVPEYNQMVKDSFKAEAEAISANNPKITASIVNKW 141
            .::|...|...|...::.|||.:::.:......::.|::|..|:||.|.:..:.....|..:|.|
Zfish    92 LRNLSQALSTDEEQYVVRLANSLFLQSGVHFNEDFLQLMKKYFRAEVETVDFSQSTAVAERINSW 156

  Fly   142 VDTQTSGKIRDLVMPSDVANLVLVIL-NAIYFKGQWQKKFNTEQTKS-DFHISDQKSVPVQMMSL 204
            |...|..||::||...|.::..:::| ||:||:|.|:.:|..|.|:: .|...|...|...||..
Zfish   157 VLNHTESKIQNLVSAEDFSSSTMIMLVNAVYFRGSWKNQFRPENTRTFSFTRDDGSEVQTLMMYQ 221

  Fly   205 VRPF--GVSYD--RELGA--NVIELPYRNSNLSMVIFLPDKVDGLPELE-----KKMVGFTPKLI 258
            ...|  |...|  .|.|.  .|:|:.|...::||:|.||.:...|..||     ..:..:...:.
Zfish   222 QGDFYYGEFSDGTTEAGGVYQVLEMLYEGEDMSMMIVLPRQEVPLASLEPIIKAPLLEEWANNVK 286

  Fly   259 NINVHLRLPKFKIEFSARLEQVLIAMGIQDAFKTSADFNDLVA----NSGAHVGGVVHKAFLEVN 319
            ...|.:.||:||:|....|.:.|..:||:..|...||.:.:.|    .....:|..|.||:|||.
Zfish   287 RQKVEVYLPRFKVEQKIDLRESLQQLGIRSIFSKDADLSAMTAQMTDGQDLFIGKAVQKAYLEVT 351

  Fly   320 EEGSEAAAATAVVFRYKSIRSPPMDFNVNHPFAYVIRDAE--NIYFQGHFVNPEL 372
            |||:|.||.:.::...:::...| ....:|||.::||:.:  :|.|.|..:||||
Zfish   352 EEGAEGAAGSGMIALTRTLVLYP-QVMADHPFFFIIRNRKTGSILFMGRVMNPEL 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn38F	NP_524956.2	Serpin	14..370	CDD:278507	110/375 (29%)
serpini1	NP_001122164.1	SERPIN	25..414	CDD:294093	115/380 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.930