DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn38F and SERPINE2

DIOPT Version :9

Sequence 1:	NP_524956.2	Gene:	Spn38F / 49806	FlyBaseID:	FBgn0028986	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	XP_005246698.1	Gene:	SERPINE2 / 5270	HGNCID:	8951	Length:	410	Species:	Homo sapiens

Alignment Length:	404	Identity:	114/404 - (28%)
Similarity:	191/404 - (47%)	Gaps:	45/404 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YLCLLLLAT----SVSCRFTD------------DLYQLLAKENADKNLITSPLSVEIALSLAYMG 51
            :|.|.|||:    |:...|..            .::..:.|.....|::.||..:...|.:..:|
Human    16 HLPLFLLASVTLPSICSHFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLG 80

  Fly    52 ARGKTAQEMRDVLKLPDDKKEVAAKFKDLLSKLEGRESVAILSLANRIYVNNKFKLVPEYNQMVK 116
            |.|:|.:::..|::.  ....|....|.:...:..:::..|:::||.::|.|..::...:....|
Human    81 ADGRTKKQLAMVMRY--GVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNK 143

  Fly   117 DSFKAEAEAISANNPKITASIVNKWVDTQTSGKIRDLVMPSDVANLV--LVILNAIYFKGQWQKK 179
            |.|:.|...::..:|......:|.||..:|...|.:|:.|..:..::  ||::||:||||.|:.:
Human   144 DVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSR 208

  Fly   180 FNTEQTKS-DFHISDQKSVPVQM---MSLVRPFGVSYDRELGANVIELPYRNSNLSMVIFLPDKV 240
            |..|.||. .|..:|.||..|.|   :|:.|....|...:|..|.|||||...::||:|.||.:.
Human   209 FQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTES 273

  Fly   241 DG-----LPELEKKMVG-----FTPKLININVHLRLPKFKIEFSARLEQVLIAMGIQDAFKTS-A 294
            ..     :|.:..|.:.     ..||    .|.:.||||.......|::.|..:||.|.|.:| |
Human   274 STPLSAIIPHISTKTIDSWMSIMVPK----RVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKA 334

  Fly   295 DFNDLVANS-GAHVGGVVHKAFLEVNEEGSEAAAATAVVFRYKSIRSPPMDFNVNHPFAYVIRDA 358
            :|..:...| ..||..::.||.:||:|:|::|:|||..:...:|  |||. |.|:.||.:.||..
Human   335 NFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARS--SPPW-FIVDRPFLFFIRHN 396

  Fly   359 EN--IYFQGHFVNP 370
            ..  :.|.|....|
Human   397 PTGAVLFMGQINKP 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn38F	NP_524956.2	Serpin	14..370	CDD:278507	107/387 (28%)
SERPINE2	XP_005246698.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.030