DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn38F and SERPINF1

DIOPT Version :9

Sequence 1:	NP_524956.2	Gene:	Spn38F / 49806	FlyBaseID:	FBgn0028986	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_001316832.1	Gene:	SERPINF1 / 5176	HGNCID:	8824	Length:	418	Species:	Homo sapiens

Alignment Length:	388	Identity:	106/388 - (27%)
Similarity:	187/388 - (48%)	Gaps:	52/388 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LATSVSCRFTDDLYQLLAKENADKNLITSPLSVEIALSLAYMGARGKTAQEMR-----DVLKLPD 68
            ||.:|| .|..|||::.:..:...|::.|||||..|||...:||..:|...:.     |::..||
Human    54 LAAAVS-NFGYDLYRVRSSTSPTTNVLLSPLSVATALSALSLGAEQRTESIIHRALYYDLISSPD 117

  Fly    69 DKKEVAAKFKDLLSKLEGRESVAILSLANRIYVNNKFKLVPEYNQMVKDSFKAEAE-------AI 126
                :...:|:||..:...:.  .|..|:||....|.:        :|.||.|..|       .:
Human   118 ----IHGTYKELLDTVTAPQK--NLKSASRIVFEKKLR--------IKSSFVAPLEKSYGTRPRV 168

  Fly   127 SANNPKITASIVNKWVDTQTSGKIRDLV--MPSDVANLVLVILNAIYFKGQWQKKFNTEQTK-SD 188
            ...||::....:|.||..|..||:....  :|.:::   :::|...:|||||..||::.:|. .|
Human   169 LTGNPRLDLQEINNWVQAQMKGKLARSTKEIPDEIS---ILLLGVAHFKGQWVTKFDSRKTSLED 230

  Fly   189 FHISDQKSVPVQMMS---LVRPFGVSYDRELGANVIELPYRNSNLSMVIFLPDKV-DGLPELEKK 249
            |::.::::|.|.|||   .|..:|:  |.:|...:.:||...| :|::.|||.|| ..|..:|:.
Human   231 FYLDEERTVRVPMMSDPKAVLRYGL--DSDLSCKIAQLPLTGS-MSIIFFLPLKVTQNLTLIEES 292

  Fly   250 MVG-----FTPKLININVHLRLPKFKIEFSARLEQVLIAMGIQDAFKTSADFNDLVANSGAHVGG 309
            :..     ...:|..:...|.:||.|:.:...:.:.|..|.:|..| .|.||:. :......:..
Human   293 LTSEFIHDIDRELKTVQAVLTVPKLKLSYEGEVTKSLQEMKLQSLF-DSPDFSK-ITGKPIKLTQ 355

  Fly   310 VVHKAFLEVNEEGSEAAAATAVVFRYKSIRSPPMDFNVNHPFAYVIRDAEN--IYFQGHFVNP 370
            |.|:|..|.||:|:....:..:...:.:.   |:|:::|.||.:|:||.:.  :.|.|..::|
Human   356 VEHRAGFEWNEDGAGTTPSPGLQPAHLTF---PLDYHLNQPFIFVLRDTDTGALLFIGKILDP 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn38F	NP_524956.2	Serpin	14..370	CDD:278507	102/381 (27%)
SERPINF1	NP_001316832.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..39
		PEDF	40..415	CDD:239007	105/386 (27%)
		O-glycosylated at one site	371..383		0/11 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010