DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn38F and SERPINA5

DIOPT Version :9

Sequence 1:	NP_524956.2	Gene:	Spn38F / 49806	FlyBaseID:	FBgn0028986	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_000615.3	Gene:	SERPINA5 / 5104	HGNCID:	8723	Length:	406	Species:	Homo sapiens

Alignment Length:	407	Identity:	123/407 - (30%)
Similarity:	195/407 - (47%)	Gaps:	47/407 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LCLLLL----------------------------ATSVSCRFTDDLYQLLAKENADKNLITSPLS 40
            |||:||                            |.|....||.|||:.||.....:::..||:|
Human     7 LCLVLLSPQGASLHRHHPREMKKRVEDLHVGATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVS 71

  Fly    41 VEIALSLAYMGARGKTAQEMRDVLKL---PDDKKEVAAKFKDLLSKLEGRESVAILSLANRIYVN 102
            :.::|::..:||...|..::.:.|.|   ...:||:...|:.||.:|........|||.|.::.:
Human    72 ISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTD 136

  Fly   103 NKFKLVPEYNQMVKDSFKAEAEAISANNPKITASIVNKWVDTQTSGKIRDLVMPSDVANLVLVIL 167
            ....|...:...:|..:.|:....:..:.......:|.:|..||.|||.||:...| :|.|::::
Human   137 LVVDLQDTFVSAMKTLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLD-SNAVVIMV 200

  Fly   168 NAIYFKGQWQKKFNTEQT-KSDFHISDQKSVPVQMMSLVRPFGVSYDRELGANVIELPYRNSNLS 231
            |.|:||.:|:..||.:.| :.||:::.:..|.|.|||....:....||.|...|:.:||: .|.:
Human   201 NYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQ-GNAT 264

  Fly   232 MVIFLPDK------VDGLPE--LEKKMVGFTPKLININVHLRLPKFKIEFSARLEQVLIAMGIQD 288
            .:..||.:      .:||.|  |.|.:..|..:    .:.|.||||.||.|.:||:||.::||.:
Human   265 ALFILPSEGKMQQVENGLSEKTLRKWLKMFKKR----QLELYLPKFSIEGSYQLEKVLPSLGISN 325

  Fly   289 AFKTSADFNDLVANSGAHVGGVVHKAFLEVNEEGSEAAAATAVVFRYKSIRSPPMDFNVNHPFAY 353
            .|.:.||.:.:..:|...|..:||||.:||:|.|:.|||||..:|.::|.|........|.||..
Human   326 VFTSHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLM 390

  Fly   354 VIRDAENIYFQGHFVNP 370
            .|.| .||.|.|....|
Human   391 FIVD-NNILFLGKVNRP 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn38F	NP_524956.2	Serpin	14..370	CDD:278507	115/367 (31%)
SERPINA5	NP_000615.3	alpha-1-antitrypsin_like	44..403	CDD:239011	115/365 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010