DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn38F and serpine2

DIOPT Version :9

Sequence 1:	NP_524956.2	Gene:	Spn38F / 49806	FlyBaseID:	FBgn0028986	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_956478.1	Gene:	serpine2 / 393153	ZFINID:	ZDB-GENE-040426-848	Length:	395	Species:	Danio rerio

Alignment Length:	398	Identity:	122/398 - (30%)
Similarity:	196/398 - (49%)	Gaps:	48/398 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLLATSVS--------CRFTD---DLYQLLAKENADKNLITSPLSVEIALSLAYMGARGKTAQEM 60
            ||.:.|||        .|.:|   .::..:.::.|.:|::.||..|...|.:...||.|.|.:::
Zfish    12 LLCSVSVSQSQSSSYGARGSDLGLQVFMQVLQDRAQENVLLSPHGVASVLGMLLPGAHGDTRRQL 76

  Fly    61 RDVLKLPDDKKEVAAK-FKDLLSKLEGRESVAILSLANRIYVNNKFKLVPEYNQMVKDSFKAEAE 124
            .:.||.   ||....| .:.|...|..:.:..|:::||.::.|..|.:..::....:::|..|:.
Zfish    77 LNGLKY---KKNGPYKMLRKLHKSLTTKSNADIVTIANALFPNEGFSMKEDFLSANRENFLCESH 138

  Fly   125 AISANNPKITASIVNKWVDTQTSGKIRDLVMPS--DVANLVLVILNAIYFKGQWQKKFNTEQTK- 186
            ::..::|:..|..:|.||...|.|:|..:|...  |.|...||.:|:|:|||.|:.:|..:.||
Zfish   139 SVDYSDPEAAAQSINDWVKNSTKGQIPSVVTADMFDTALTRLVAVNSIFFKGLWKSRFQPQSTKP 203

  Fly   187 SDFHISDQKSVPVQMMSLV---------RPFGVSYDRELGANVIELPYRNSNLSMVIFLPDKVDG 242
            ..|...|..:..|.|||.:         .|.|..|      .||||||..:::||.|.||.: |.
Zfish   204 RSFTAGDGNTYKVPMMSQLSVFNMGQASTPDGQKY------IVIELPYHGNSMSMFIALPTE-DS 261

  Fly   243 ------LPELEKKMVGFTPKLIN-INVHLRLPKFKIEFSARLEQVLIAMGIQDAF-KTSADFNDL 299
                  ||.:....:....||:| ..:.|.:|||.:|....||..|.|:||:|.| :..|||..|
Zfish   262 TPLSSILPHISTNTIQSWTKLMNPRRMRLLMPKFTVEQELDLETPLKALGIKDIFDQNKADFRHL 326

  Fly   300 VANSGAHVGGVVHKAFLEVNEEGSEAAAATAVVFRYKSIRSPPMDFNVNHPFAYVIR--DAENIY 362
            .:.| .:|...:.||.:||||:|::|:|.|:|:...:|  |||. ..|:.||.::||  .:..|.
Zfish   327 SSES-IYVSKALQKAKIEVNEDGTKASATTSVILHARS--SPPW-VTVDRPFLFLIRHNSSGTIL 387

  Fly   363 FQGHFVNP 370
            |.|....|
Zfish   388 FAGQINKP 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn38F	NP_524956.2	Serpin	14..370	CDD:278507	117/389 (30%)
serpine2	NP_956478.1	PAI-1_nexin-1	26..395	CDD:239006	116/382 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.030