DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn38F and Serpinb1c

DIOPT Version :9

Sequence 1:	NP_524956.2	Gene:	Spn38F / 49806	FlyBaseID:	FBgn0028986	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	XP_006516771.1	Gene:	Serpinb1c / 380839	MGIID:	2445363	Length:	408	Species:	Mus musculus

Alignment Length:	379	Identity:	132/379 - (34%)
Similarity:	209/379 - (55%)	Gaps:	27/379 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TSVSCRFTDDLYQLLAKENADKNLITSPLSVEIALSLAYMGARGKTAQEMRDVLKLPDDKKEVAA 75
            :|.:..|..:|:..|.:.|...|.|.||:|:..||::.|:||||.||.::...|.. |..:::.:
Mouse    38 SSANNLFALELFHTLNESNPTGNTIFSPVSISSALAMVYLGARGSTAAQLSKTLHF-DSAEDIHS 101

  Fly    76 KFKDLLSKLEGRESVAILSLANRIYVNNKFKLVPEYNQMVKDSFKAEAEAISANNPKITA-SIVN 139
            :|:.|.:::..|.:...|.||||:|....:..:|||...::.::.|:...:...:....| ..:|
Mouse   102 QFQSLTAEVSKRGASHTLKLANRLYGEKTYNFLPEYLASIQKTYSADLALVDFQHASEDARKEIN 166

  Fly   140 KWVDTQTSGKIRDLVMPSDVANLV-LVILNAIYFKGQWQKKFNT-EQTKSDFHISDQKSVPVQMM 202
            :||..||..||::|.....|.::. ||::||.||||.|||||.. :.|.:.|.:|.:.:..|:||
Mouse   167 QWVKGQTEEKIQELFAVGVVDSMTKLVLVNATYFKGMWQKKFMARDTTDAPFRLSKKVTKTVKMM 231

  Fly   203 SLVR--PFGVSYDRELGANVIELPYRNSNLSMVIFLP----DKVDGLPELEKKM----VGFTPKL 257
            .|..  |||  |..:|...|:|:||:...|||||.||    |:..||.|:||::    :.....|
Mouse   232 YLKNNLPFG--YIPDLKCKVLEMPYQGGELSMVILLPEDIEDETTGLEEIEKQLTLEKLQECENL 294

  Fly   258 ININVHLRLPKFKIEFSARLEQVLIAMGIQDAFKTS-ADFNDLVANSGAHVGGVVHKAFLEVNEE 321
            .||:|.::|||||:|.|..|...|..:|:||.|.:| ||.:.:..:....:..:|||:::|||||
Mouse   295 QNIDVCVKLPKFKMEESYILNSNLGQLGVQDLFSSSKADLSGMSGSRDLFISKIVHKSYVEVNEE 359

  Fly   322 GSEAAAA---TAVVFRYKSIRSPPMDFNVNHPFAYVIR--DAENIYFQGHFVNP 370
            |:|..||   |.|     .....||:|.|:|||.:.||  ...::.|.|...:|
Mouse   360 GTETDAAMPGTVV-----GCCLMPMEFTVDHPFLFFIRHNPTAHVLFLGRVCSP 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn38F	NP_524956.2	Serpin	14..370	CDD:278507	130/374 (35%)
Serpinb1c	XP_006516771.1	serpinB1_LEI	34..408	CDD:381028	131/377 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	1	1.000	-	-		otm44055
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.930