DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn38F and SERPIND1

DIOPT Version :9

Sequence 1:	NP_524956.2	Gene:	Spn38F / 49806	FlyBaseID:	FBgn0028986	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_000176.2	Gene:	SERPIND1 / 3053	HGNCID:	4838	Length:	499	Species:	Homo sapiens

Alignment Length:	378	Identity:	103/378 - (27%)
Similarity:	189/378 - (50%)	Gaps:	30/378 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VSCRFTDDLYQLLAKE-NADKNLITSPLSVEIALSLAYMGARGKTAQEMRDVLKLPD-----DKK 71
            ::.:|..:||::|..: |...|:..:|:.:..|:.:..:|.:|:|.:::..:|...|     .|.
Human   129 LNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKY 193

  Fly    72 EVAA---KFKDLLSKLEGRESVAILSLANRIYVNNKFKLVPEYNQMVKDSFKAEAEAISANNPKI 133
            |:..   .|:.|..:|..|.....|...|.:|:..:|.::.::...|::.:.|||:....::|..
Human   194 EITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAF 258

  Fly   134 TASIVNKWVDTQTSGKIRDLVMPSDVANLVLVILNAIYFKGQWQKKFNTEQTKS-DFHISDQKSV 197
             .|..|..:...|.|.|:|.:...|.|. .::|||.|||||.|..||..|.|.: :|.:::::.|
Human   259 -ISKTNNHIMKLTKGLIKDALENIDPAT-QMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVV 321

  Fly   198 PVQMMSLVRPFGVSYDRELGANVIELPYRNSNLSMVIFLPDKVDGLPELEKKMVGFTPKLI---- 258
            .|.||.....|..:.|:||..::::|.| ...:||:|.:|.|:.|:..||.::   ||:::
Human   322 KVSMMQTKGNFLAANDQELDCDILQLEY-VGGISMLIVVPHKMSGMKTLEAQL---TPRVVERWQ 382

  Fly   259 ----NINVHLRLPKFKIEFSARLEQVLIAMGIQDAFKTSADFNDLVANSGAHVGGVVHKAFLEVN 319
                |....:.|||||:|.:..|.:.|..|||:..|..:.:... :::....:....|:..:.||
Human   383 KSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAG-ISDQRIAIDLFKHQGTITVN 446

  Fly   320 EEGSEAAAATAVVFRYKSIRSPPMDFNVNHPFAYVIRDAEN--IYFQGHFVNP 370
            |||::|...|.|.|...|.:   :.|.|:.||.::|.:...  :.|.|...||
Human   447 EEGTQATTVTTVGFMPLSTQ---VRFTVDRPFLFLIYEHRTSCLLFMGRVANP 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn38F	NP_524956.2	Serpin	14..370	CDD:278507	101/375 (27%)
SERPIND1	NP_000176.2	HCII	62..497	CDD:239002	103/378 (27%)
		Chemotactic activity	68..79
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	73..97
		Glycosaminoglycan-binding site	192..212		5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020