DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn38F and Serpinb12

DIOPT Version :9

Sequence 1:	NP_524956.2	Gene:	Spn38F / 49806	FlyBaseID:	FBgn0028986	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	XP_038946584.1	Gene:	Serpinb12 / 304692	RGDID:	1566382	Length:	423	Species:	Rattus norvegicus

Alignment Length:	417	Identity:	130/417 - (31%)
Similarity:	219/417 - (52%)	Gaps:	65/417 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RFTDDLYQLLAKENADKNLITSPLSVEIALSLAYMGARGKTAQEMRDVL---KLP-DDKKE---- 72
            :|..|.:|.::|::|.||:...|||:..|..:..:||||.:||::.:||   :|| |::||
  Rat    10 KFCFDFFQEISKDDAHKNIFVCPLSLSAAFGMVRLGARGDSAQQIDEVLHFNELPKDERKEPSEP 74

  Fly    73 -----------------------------------VAAKFKDLLSKLEGRESVAILSLANRIYVN 102
                                               :...|..|||:::..::...||:|||:|..
  Rat    75 SSKSKASDSSLEGQKQTTASQGQQVSGESTNEHRLLGCHFGKLLSRIDRDKAHYTLSMANRLYGE 139

  Fly   103 NKFKLVPEYNQMVKDSFKAEAEAIS-ANNPKITASIVNKWVDTQTSGKIRDLVMPSDVAN-LVLV 165
            .:|.:.|||:..:.:.:....|::. ..:.:.:...:|.||::|:.|||::|.....:.| .|||
  Rat   140 QEFPICPEYSDDITEFYHTTIESVDFQKDTEKSREEINFWVESQSQGKIKELFDKEAIDNSTVLV 204

  Fly   166 ILNAIYFKGQWQKKFNTEQT-KSDFHISDQKSVPVQMMSLVRPFGVSYDRELGANVIELPYRNSN 229
            ::||:|||.:|:|:|::|.| .:.|.:|:.:...|:||:....|.:.:..||.|.::|:.|....
  Rat   205 LVNAVYFKAKWEKEFDSENTVDAPFCLSENEKKTVKMMNQKGQFRIGFIEELQAQILEMKYTTGK 269

  Fly   230 LSMVIFLP----DKVDGLPELEKK------MVGFTPKLININ---VHLRLPKFKIEFSARLEQVL 281
            |||::.||    |.|..|.|||||      :....|:  |::   |.:..|:|.:|.|..|..||
  Rat   270 LSMLVLLPSSSEDNVKSLQELEKKINHEKLLAWSNPE--NMSEKPVAISFPQFIMEDSYDLNSVL 332

  Fly   282 IAMGIQDAFK-TSADFNDLVANSGAHVGGVVHKAFLEVNEEGSEAAAATAVVFRYKSIRSPPMDF 345
            ..|||:|.|. |.||...:..:...|:..||||.|:||:|.|::||||:..|...|::.| .::|
  Rat   333 QDMGIRDVFDGTKADLTGISKSPSLHLSKVVHKTFVEVDEMGTQAAAASGAVVAEKALPS-RVEF 396

  Fly   346 NVNHPFAYVIR--DAENIYFQGHFVNP 370
            |.|.||.:.||  ..:::.|.|...:|
  Rat   397 NANRPFLFFIRHNGTQSLLFCGRVYSP 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn38F	NP_524956.2	Serpin	14..370	CDD:278507	129/415 (31%)
Serpinb12	XP_038946584.1	serpinB12_yukopin	1..423	CDD:381037	129/415 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	1	1.000	-	-		otm46144
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.930