DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn38F and Serpinh1

DIOPT Version :9

Sequence 1:	NP_524956.2	Gene:	Spn38F / 49806	FlyBaseID:	FBgn0028986	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_058869.2	Gene:	Serpinh1 / 29345	RGDID:	69302	Length:	417	Species:	Rattus norvegicus

Alignment Length:	381	Identity:	100/381 - (26%)
Similarity:	183/381 - (48%)	Gaps:	29/381 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ATSVSCRFTD---DLYQLLAKENADKNLITSPLSVEIALSLAYMGARGKTAQEMRDVL---KLPD 68
            ||:::.|.|.   .|||.:||:.|.:|::.|||.|..:|.|..:|.:..||.:.:.||   ||.|
  Rat    39 ATTLAERSTGLAFSLYQAMAKDQAVENILLSPLVVASSLGLVSLGGKATTASQAKAVLSAEKLRD 103

  Fly    69 DKKEVAAKFKDLLSKLEGRESVAIL-SLANRIYVNNKFKLVPEYNQMVKDSFKAEAEAISANNPK 132
            :  ||.....:||..|....:..:. .|.:|:|..:......::.:..|..:..|...|:..:.:
  Rat   104 E--EVHTGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKR 166

  Fly   133 ITASIVNKWVDTQTSGKIRDL---VMPSDVANLVLVILNAIYFKGQWQKKFNTEQTKS-DFHISD 193
            .....:|:|....|.||:.::   |..:|.|.||    ||::||..|.:||:.:...: .|.::.
  Rat   167 SALQSINEWASQTTDGKLPEVTKDVERTDGALLV----NAMFFKPHWDEKFHHKMVDNRGFMVTR 227

  Fly   194 QKSVPVQMMSLVRPFGVSYDRELGANVIELPYRNSNLSMVIFLPDKVDGLPELEK-----KMVGF 253
            ..:|.|.||.....:....|.:....::|:|..:...|::|.:|..|:.|..|||     ::..:
  Rat   228 SYTVGVTMMHRTGLYNYYDDEKEKLQLVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKTW 292

  Fly   254 TPKLININVHLRLPKFKIEFSARLEQVLIAMGIQDAF-KTSADFNDLVANSGAHVGGVVHKAFLE 317
            ..|:....|.:.|||..:|.:..|::.|..:|:.:|. |..||.:.:......::..|.|....|
  Rat   293 MGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFE 357

  Fly   318 VNEEGSEAAAATAVVFRYKSIRSPPMDFNVNHPFAYVIRDAE--NIYFQGHFVNPE 371
            .:.||:   .....::..:.:|||.: |..:|||.:::||.:  ::.|.|..|.|:
  Rat   358 WDTEGN---PFDQDIYGREELRSPKL-FYADHPFIFLVRDNQSGSLLFIGRLVRPK 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn38F	NP_524956.2	Serpin	14..370	CDD:278507	97/374 (26%)
Serpinh1	NP_058869.2	serpinH1_CBP1	35..416	CDD:381003	100/381 (26%)
Serpinh1	NP_058869.2	Prevents secretion from ER. /evidence=ECO:0000305	414..417
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920