Protein Alignment Spn38F and SERPINB1

DIOPT Version :10

• Sequence 1: NP_524956.2
• Gene: Spn38F / 49806
• FlyBaseID: FBgn0028986
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_109591.1
• Gene: SERPINB1 / 1992
• HGNCID: 3311
• Length: 379
• Species: Homo sapiens
• Alignment Length: 379
• Identity: 133/379 - (35%)
• Similarity: 214/379 - (56%)
• Gaps: 23/379 - (6%)

  Fly    11 TSVSCRFTDDLYQLLAKENADKNLITSPLSVEIALSLAYMGARGKTAQEMRDVLKLPDDKKEVAA 75
            :|.:.||..||:..|::.|...|:..||.|:..|:::.::|.||.||.::...... :..:||.:
Human     5 SSANTRFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKTFHF-NTVEEVHS 68

  Fly    76 KFKDLLSKLEGRESVAILSLANRIYVNNKFKLVPEYNQMVKDSFKAEAEAISANNPKITA-SIVN 139
            :|:.|.:.:..|.:..||.||||:|....:..:||:....:.::.|:..::...:....| ..:|
Human    69 RFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVDFQHASEDARKTIN 133

  Fly   140 KWVDTQTSGKIRDLVMPSDVANLV-LVILNAIYFKGQWQKKFNTE-QTKSDFHISDQKSVPVQMM 202
            :||..||.|||.:|:....|.|:. ||::|||||||.|:.||..| .|.:.|.::.:....|:||
Human   134 QWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRLNKKDRKTVKMM 198

  Fly   203 SLVRPFGVSYDRELGANVIELPYRNSNLSMVIFLPDKVD----GLPELE-----KKMVGFT-PKL 257
            ...:.|...|..:|...|:||||:...|||||.|||.::    ||.::|     :|:..:| |:.
Human   199 YQKKKFAYGYIEDLKCRVLELPYQGEELSMVILLPDDIEDESTGLKKIEEQLTLEKLHEWTKPEN 263

  Fly   258 IN-INVHLRLPKFKIEFSARLEQVLIAMGIQDAFKTSADFNDLVANSGAH---VGGVVHKAFLEV 318
            :: |.|::.||:||:|.|..|...|..:|:||.|.:|.  .||...|||.   :..:|||:|:||
Human   264 LDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFNSSK--ADLSGMSGARDIFISKIVHKSFVEV 326

  Fly   319 NEEGSEAAAATAVVFRYKSIRSPPMDFNVNHPFAYVIR--DAENIYFQGHFVNP 370
            ||||:|||||||.:..: .:..|..:|..:|||.:.||  .:.:|.|.|.|.:|
Human   327 NEEGTEAAAATAGIATF-CMLMPEENFTADHPFLFFIRHNSSGSILFLGRFSSP 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn38F	NP_524956.2	serpin42Dd-like_insects	12..370	CDD:381070	132/376 (35%)
SERPINB1	NP_109591.1	serpinB1_LEI	1..379	CDD:381028	132/377 (35%)
		CARD-binding motif (CBM). /evidence=ECO:0000269|PubMed:30692621	351..379		10/27 (37%)