DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn38F and SERPINB1

DIOPT Version :9

Sequence 1:	NP_524956.2	Gene:	Spn38F / 49806	FlyBaseID:	FBgn0028986	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_109591.1	Gene:	SERPINB1 / 1992	HGNCID:	3311	Length:	379	Species:	Homo sapiens

Alignment Length:	379	Identity:	133/379 - (35%)
Similarity:	214/379 - (56%)	Gaps:	23/379 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TSVSCRFTDDLYQLLAKENADKNLITSPLSVEIALSLAYMGARGKTAQEMRDVLKLPDDKKEVAA 75
            :|.:.||..||:..|::.|...|:..||.|:..|:::.::|.||.||.::...... :..:||.:
Human     5 SSANTRFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKTFHF-NTVEEVHS 68

  Fly    76 KFKDLLSKLEGRESVAILSLANRIYVNNKFKLVPEYNQMVKDSFKAEAEAISANNPKITA-SIVN 139
            :|:.|.:.:..|.:..||.||||:|....:..:||:....:.::.|:..::...:....| ..:|
Human    69 RFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVDFQHASEDARKTIN 133

  Fly   140 KWVDTQTSGKIRDLVMPSDVANLV-LVILNAIYFKGQWQKKFNTE-QTKSDFHISDQKSVPVQMM 202
            :||..||.|||.:|:....|.|:. ||::|||||||.|:.||..| .|.:.|.::.:....|:||
Human   134 QWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRLNKKDRKTVKMM 198

  Fly   203 SLVRPFGVSYDRELGANVIELPYRNSNLSMVIFLPDKVD----GLPELE-----KKMVGFT-PKL 257
            ...:.|...|..:|...|:||||:...|||||.|||.::    ||.::|     :|:..:| |:.
Human   199 YQKKKFAYGYIEDLKCRVLELPYQGEELSMVILLPDDIEDESTGLKKIEEQLTLEKLHEWTKPEN 263

  Fly   258 IN-INVHLRLPKFKIEFSARLEQVLIAMGIQDAFKTSADFNDLVANSGAH---VGGVVHKAFLEV 318
            :: |.|::.||:||:|.|..|...|..:|:||.|.:|.  .||...|||.   :..:|||:|:||
Human   264 LDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFNSSK--ADLSGMSGARDIFISKIVHKSFVEV 326

  Fly   319 NEEGSEAAAATAVVFRYKSIRSPPMDFNVNHPFAYVIR--DAENIYFQGHFVNP 370
            ||||:|||||||.:..: .:..|..:|..:|||.:.||  .:.:|.|.|.|.:|
Human   327 NEEGTEAAAATAGIATF-CMLMPEENFTADHPFLFFIRHNSSGSILFLGRFSSP 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn38F	NP_524956.2	Serpin	14..370	CDD:278507	131/374 (35%)
SERPINB1	NP_109591.1	SERPIN	4..379	CDD:294093	132/377 (35%)
SERPINB1	NP_109591.1	CARD-binding motif (CBM). /evidence=ECO:0000269\|PubMed:30692621	351..379		10/27 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	1	1.000	-	-		mtm8652
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10598
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.960