DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn38F and Serpind1

DIOPT Version :9

Sequence 1:	NP_524956.2	Gene:	Spn38F / 49806	FlyBaseID:	FBgn0028986	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_001317976.1	Gene:	Serpind1 / 15160	MGIID:	96051	Length:	478	Species:	Mus musculus

Alignment Length:	379	Identity:	110/379 - (29%)
Similarity:	194/379 - (51%)	Gaps:	32/379 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VSCRFTDDLYQLLAKENA--DKNLITSPLSVEIALSLAYMGARGKTAQEMRDVLKLPD-----DK 70
            ::.:|..:||::| |:.|  ..||..:|:.:..|:.:..:|.||:|.:|:..||...|     .|
Mouse   108 LNAKFAFNLYRVL-KDQATTSDNLFIAPVGISTAMGMISLGLRGETHEEVHSVLHFRDFVNASSK 171

  Fly    71 KEVAA---KFKDLLSKLEGRESVAILSLANRIYVNNKFKLVPEYNQMVKDSFKAEAEAISANNPK 132
            .||..   .|:.|..:|..|.....|...|.:|:..:|.:..::...:::.:.|||:..:..:|.
Mouse   172 YEVTTIHNLFRKLTHRLFRRNFGYTLRSVNGLYIQKQFPIREDFKAAMREFYFAEAQEANFPDPA 236

  Fly   133 ITASIVNKWVDTQTSGKIRDLVMPSDVANLVLVILNAIYFKGQWQKKFNTEQTKS-DFHISDQKS 196
            . .|..|..:...|.|.|::.:...|.|..:| |||.|||||.|..||..|.|.: :|.:::::.
Mouse   237 F-ISKANNHILKLTKGLIKEALENIDPATQML-ILNCIYFKGTWVNKFPVEMTHNHNFRLNEREV 299

  Fly   197 VPVQMMSLVRPFGVSYDRELGANVIELPYRNSNLSMVIFLPDKVDGLPELEKKMVGFTPKLI--- 258
            |.|.||.....|..:.|:||..::::|.| ...:||:|.:|.|:.|:..||.::   ||:::
Mouse   300 VKVSMMQTKGNFLAANDQELDCDILQLEY-VGGISMLIVVPRKLSGMKTLEAQL---TPQVVERW 360

  Fly   259 -----NINVHLRLPKFKIEFSARLEQVLIAMGIQDAFKTSADFNDLVANSGAHVGGVVHKAFLEV 318
                 |....:.|||||:|.:..|.:||.:|||...|..:.:.:. :::....:....|::.:.|
Mouse   361 QKSMTNRTREVLLPKFKLEKNYNLVEVLKSMGITKLFNKNGNMSG-ISDQRIAIDLFKHQSTITV 424

  Fly   319 NEEGSEAAAATAVVFRYKSIRSPPMDFNVNHPFAYVIRDAEN--IYFQGHFVNP 370
            ||||::|||.|.|.|...|.:   :.|.|:.||.:::.:...  :.|.|...||
Mouse   425 NEEGTQAAAVTTVGFMPLSTQ---VRFTVDRPFLFLVYEHRTSCLLFMGKVTNP 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn38F	NP_524956.2	Serpin	14..370	CDD:278507	108/376 (29%)
Serpind1	NP_001317976.1	HCII	43..476	CDD:239002	110/379 (29%)
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	54..78
		Glycosaminoglycan-binding site. /evidence=ECO:0000250	171..191		6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020