DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn38F and Serping1

DIOPT Version :9

Sequence 1:	NP_524956.2	Gene:	Spn38F / 49806	FlyBaseID:	FBgn0028986	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_033906.2	Gene:	Serping1 / 12258	MGIID:	894696	Length:	504	Species:	Mus musculus

Alignment Length:	385	Identity:	100/385 - (25%)
Similarity:	171/385 - (44%)	Gaps:	67/385 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FTDDLYQLL-AKENADKNLITSPLSVEIALSLAYMGARGKTAQEMRDVLKLPDDKKEVAAKFKDL 80
            |:..||... |.:.|..|:..||.|:...|:...:||...|...:..:|..|.|       |..:
Mouse   154 FSVKLYHAFSATKMAKTNMAFSPFSIASLLTQVLLGAGDSTKSNLESILSYPKD-------FACV 211

  Fly    81 LSKLEGRESVAILSLANRIYVNNKFKLVPEYNQMVKDSFKAEAEAISANNPKI-------TASIV 138
            ...|:|..|..:.|::         ::....:..::|::...::::..::|::       ...::
Mouse   212 HQALKGFSSKGVTSVS---------QIFHSPDLAIRDTYVNASQSLYGSSPRVLGPDSAANLELI 267

  Fly   139 NKWVDTQTSGKIRDLV--MPSDVANLVLVILNAIYFKGQWQKKFNTEQTKSDFHISDQKSVPVQM 201
            |.||...|:.|||.|:  :|||..   ||:|||:|...:|:..|..::..:.|...: ..:.|.|
Mouse   268 NTWVAENTNHKIRKLLDSLPSDTC---LVLLNAVYLSAKWKITFEPKKMMAPFFYKN-SMIKVPM 328

  Fly   202 MSLVR-PFGVSYDRELGANVIELPYRNSNLSMVIFLPDKVDGLPELEKKMVGFTPKLININV--- 262
            ||.|: |.....|..|.|.|.:|.. :.|||.||.:|    ..|:.:.|.|   .|.:|..|
Mouse   329 MSSVKYPVAQFDDHTLKAKVGQLQL-SHNLSFVIVVP----VFPKHQLKDV---EKALNPTVFKA 385

  Fly   263 -------------HLRLPKFKIEFSARLEQVLIAMGIQDAFKTSADFN--DLVANSGAHVGGVVH 312
                         :|.:|..|::.|   :.:|..|...:.|..:.|.|  .|..:....|..:.|
Mouse   386 IMKKLELSKFLPTYLTMPHIKVKSS---QDMLSVMEKLEFFDFTYDLNLCGLTEDPDLQVSAMKH 447

  Fly   313 KAFLEVNEEGSEAAAATAVVFRYKSIRSPPMDFNVNHPFAYVIRDAENIY--FQGHFVNP 370
            :..||:.|.|.|||||:|:.|.    ||.|: |.|..||.:::.|.::.:  |.|...:|
Mouse   448 ETVLELTESGVEAAAASAISFG----RSLPI-FEVQRPFLFLLWDQQHRFPVFMGRVYDP 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn38F	NP_524956.2	Serpin	14..370	CDD:278507	99/383 (26%)
Serping1	NP_033906.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..67
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..141
		serpinG1_C1-INH	141..500	CDD:381006	99/381 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010