DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn42Da and SERPINH1

DIOPT Version :9

Sequence 1:	NP_524955.2	Gene:	Spn42Da / 49805	FlyBaseID:	FBgn0265137	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001193943.1	Gene:	SERPINH1 / 871	HGNCID:	1546	Length:	418	Species:	Homo sapiens

Alignment Length:	393	Identity:	94/393 - (23%)
Similarity:	169/393 - (43%)	Gaps:	26/393 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 TADVTMADAAHQEFARRLALFSINVYGKLSGQKPGENIVFSPFSIQTCAAMARLGAENETATQLD 92
            ||:.....||  ..|.|.|..:.::|..::..:..|||:.||..:.:...:..||.:..||:|..
Human    32 TAEKLSPKAA--TLAERSAGLAFSLYQAMAKDQAVENILVSPVVVASSLGLVSLGGKATTASQAK 94

  Fly    93 QGLGLASSDPEQIAHSFHQVLAAYQDSQ----ILRIANKIFVMDGYQLRQEFDQLLSKQFLSAAQ 153
            ..|.......|::.....::|.:..:|.    ..::.::::.........:|.: .|||..:...
Human    95 AVLSAEQLRDEEVHAGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVR-SSKQHYNCEH 158

  Fly   154 S-VDFSKNVQAAATINNWVEQRTNHLIKDLVPADVLNSESRLVLVNAIHFKGTWQHQFAKHLTRP 217
            | ::|.....|..:||.|..|.|:..:.: |..||..::..| ||||:.||..|..:|...:...
Human   159 SKINFRDKRSALQSINEWAAQTTDGKLPE-VTKDVERTDGAL-LVNAMFFKPHWDEKFHHKMVDN 221

  Fly   218 DTFHLDGERTVQVPMMSLKERFRYADLPALDAMALELPYKDSDLSMLIVLPNTKTGLPALEEKLR 282
            ..|.:....||.|.||.....:.|.|........:|:|......|::|::|:....|..||:.|.
Human   222 RGFMVTRSYTVGVMMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLT 286

  Fly   283 LTTLSQITQSLYETKVALKLPRFKAEFQVELSEVFQKLGMSRMF-SDQAEFGKMLQSPEPLKVSA 346
            ...|......:.:..||:.||:...|...:|.:....||::... .::|:..:| ...:.|.:::
Human   287 KEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRM-SGKKDLYLAS 350

  Fly   347 IIHKAFIEVNEEGTEAAAATGMAVRRKRAIMSPEE---PIEFFADHPFTYVLVH-QKDLPLFWGS 407
            :.|....|::.:|...          .:.|...||   |..|:|||||.:::.. |....||.|.
Human   351 VFHATAFELDTDGNPF----------DQDIYGREELRSPKLFYADHPFIFLVRDTQSGSLLFIGR 405

  Fly   408 VVR 410
            :||
Human   406 LVR 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Da	NP_524955.2	SERPIN	45..408	CDD:238101	86/372 (23%)
SERPINH1	NP_001193943.1	serpinH1_CBP1	36..417	CDD:381003	92/389 (24%)
SERPINH1	NP_001193943.1	Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	415..418
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920