DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Da and SERPINA6

DIOPT Version :9

Sequence 1:	NP_524955.2	Gene:	Spn42Da / 49805	FlyBaseID:	FBgn0265137	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001747.3	Gene:	SERPINA6 / 866	HGNCID:	1540	Length:	405	Species:	Homo sapiens

Alignment Length:	401	Identity:	119/401 - (29%)
Similarity:	194/401 - (48%)	Gaps:	16/401 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDYRLVPCGCWLLPLLGLALFPFPPVHTADVTMADAAHQEFARRLALFSINVYGKLSGQKPGENI 65
            |...|..|..| ||..||........:.|.|.|:: .|:..|.....|:.::|..|....|.:||
Human     1 MPLLLYTCLLW-LPTSGLWTVQAMDPNAAYVNMSN-HHRGLASANVDFAFSLYKHLVALSPKKNI 63

  Fly    66 VFSPFSIQTCAAMARLGAENETATQLDQGLG--LASSDPEQIAHSF---HQVLAAYQDSQILRIA 125
            ..||.||....||..||....|..||.||||  |......:|...|   ||:.|....|..:.:.
Human    64 FISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKSDTSLEMTMG 128

  Fly   126 NKIFVMDGYQLRQEFDQLLSKQFLSAAQSVDFSKNVQAAATINNWVEQRTNHLIKDLVPADVLNS 190
            |.:|:....:|.:.|...:...:.|...:::|.....|:..||::|:.:|...|.||...  |:|
Human   129 NALFLDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQGKIVDLFSG--LDS 191

  Fly   191 ESRLVLVNAIHFKGTWQHQFAKHLTRPDTFHLDGERTVQVPMMSLKERFRYADLPALDAMALELP 255
            .:.|||||.|.|||||...|....||.:.|::|....|:||||.......|.....|....:::.
Human   192 PAILVLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQMN 256

  Fly   256 YKDSDLSMLIVLPNTKTGLPALEEKLRLTTLSQITQSLYETKVALKLPRFKAEFQVELSEVFQKL 320
            |..:. ::..:||: |..:..:...|...|:::.:..|..::|.|.:|:.......:|.:|.:::
Human   257 YVGNG-TVFFILPD-KGKMNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEM 319

  Fly   321 GMSRMFSDQAEFGKMLQSPEPLKVSAIIHKAFIEVNEEGTEAAAATGMAVR--RKRAIMSPEEP- 382
            |::.:|::||.|.::.|..: ||.|.::|||.:::||||.:.|.:||:.:.  .|..|:...:|
Human   320 GIADLFTNQANFSRITQDAQ-LKSSKVVHKAVLQLNEEGVDTAGSTGVTLNLTSKPIILRFNQPF 383

  Fly   383 IEFFADHPFTY 393
            |....|| ||:
Human   384 IIMIFDH-FTW 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Da	NP_524955.2	SERPIN	45..408	CDD:238101	106/357 (30%)
SERPINA6	NP_001747.3	alpha-1-antitrypsin_like	42..401	CDD:239011	106/358 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020