DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Da and Serpina3a

DIOPT Version :9

Sequence 1:	NP_524955.2	Gene:	Spn42Da / 49805	FlyBaseID:	FBgn0265137	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001161177.1	Gene:	Serpina3a / 74069	MGIID:	1921319	Length:	422	Species:	Mus musculus

Alignment Length:	421	Identity:	119/421 - (28%)
Similarity:	200/421 - (47%)	Gaps:	52/421 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LGLALFPFPPV----HTADVTMA-------DAAHQEFARRLALFSIN------VYGKLSGQKPGE 63
            |||.:....|.    .|||..:.       |..|:.....:.|.|||      :|.||:.:.|.:
Mouse     7 LGLLMAGICPAITYWATADGQLGRHTEVQKDRDHEIQLDSVTLASINTDFAFSLYKKLALKNPHK 71

  Fly    64 NIVFSPFSIQTCAAMARLGAENETATQLDQGL--GLASSDPEQIAHSF-H--QVLAAYQDSQILR 123
            ||||||.||....|:..|||::.|..::.:||  .|..:....|..:| |  |:|...::...:.
Mouse    72 NIVFSPLSISAALALMSLGAKDNTLEEILEGLKFNLTETPEADIHQNFGHLLQMLIQPENQVQIN 136

  Fly   124 IANKIFVMDGYQLRQEFDQLLSKQFLSAAQSVDFSKNVQAAATINNWVEQRTNHLIKDLVPADVL 188
            ..|.:|:....|:..||.:.....:.:.|.:.||....:|...||::|.::|...||:|| :| |
Mouse   137 AGNALFIDKHLQILTEFKEKARALYKAEAFTADFQLPREATKLINDYVRKQTQGKIKELV-SD-L 199

  Fly   189 NSESRLVLVNAIHFKGTWQHQFAKHLTRPDTFHLDGERTVQVPMMSLKE----RFRYADLPALDA 249
            :..:.:.|||.::|:|.|...|....|....|.||.:|||.||||..:|    .||..:   :.:
Mouse   200 HRNTSMALVNFLNFQGFWNVTFDPEDTFLGNFTLDRKRTVNVPMMKTEELTTNYFRDEE---MQS 261

  Fly   250 MALELPYKDSDLSMLIVLPNTKTGLPALEEKLRLTTLSQITQSLYETKV-ALKLPRFKAEFQVEL 313
            ..:||.| ..:.|.|.:||: :..:..:|:.|:..:|.:..:||....: .|.||:|.......|
Mouse   262 TVMELNY-IGNASFLFILPD-QGRIQHVEDSLQPQSLRKWRKSLRPRMLDELSLPKFSLSQDYNL 324

  Fly   314 SEVFQKLGMSRMFSDQAEFGKMLQSPEPLKVSAIIHKAFIEVNEEGTEAAAAT-----GMAVRRK 373
            :::..:||:..:||.||:... :...:.::||.:||:|.::|.|..|||...|     ..:.:.|
Mouse   325 NDILPELGIKEVFSTQADLSG-ITGAKNIRVSQMIHQAALDVTETHTEADVITIARYNFQSAKIK 388

  Fly   374 RAIMSPEEPIEFFADHPFTYVLVHQKDLPLF 404
            ..|:.        .|..|.|:::.    |:|
Mouse   389 AKIVK--------VDREFLYLILD----PMF 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Da	NP_524955.2	SERPIN	45..408	CDD:238101	110/381 (29%)
Serpina3a	NP_001161177.1	SERPIN	53..416	CDD:294093	107/375 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010