DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Da and Serpini2

DIOPT Version :9

Sequence 1:	NP_524955.2	Gene:	Spn42Da / 49805	FlyBaseID:	FBgn0265137	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_080736.2	Gene:	Serpini2 / 67931	MGIID:	1915181	Length:	405	Species:	Mus musculus

Alignment Length:	389	Identity:	118/389 - (30%)
Similarity:	207/389 - (53%)	Gaps:	14/389 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RRLALFSINVYGKLS-GQKPGENIVFSPFSIQTCAAMARLGAENETATQLDQGL---GLASSDPE 103
            :::|.|::::|..:| ..|  .||:|||........|.:|||:.:...|:.:.|   |..:.:..
Mouse    24 QKIADFAVDLYKAISLSHK--NNIIFSPLGTTMLLGMVQLGAKGKAQQQILKTLRMRGTPAGEEF 86

  Fly   104 QIAHSFHQVLAAYQDSQILRIANKIFVMDGYQLRQEFDQLLSKQFLSAAQSVDFSKNVQAAATIN 168
            .:..|....::..:......:|:.:::.:|:.:::.:.....:.|.||.:.|||.....:|..|:
Mouse    87 SVLKSLFSAISKKKQEFTFNLASALYLQEGFIVKETYLHSNKEFFQSATKLVDFLDAKTSAQAIS 151

  Fly   169 NWVEQRTNHLIKDLVPADVLNSESRLVLVNAIHFKGTWQHQFAKHLTRPDTFHLDGERTVQVPMM 233
            .|||.:|:..||::...:.....:||||||||:|||.|:.:|.|..|....|......||:||||
Mouse   152 TWVESKTDGKIKNMFSEEEFGPLTRLVLVNAIYFKGDWKQKFRKEDTEMTDFTKKDGSTVKVPMM 216

  Fly   234 S--LKERFRYADLPALDAMALELPYKDSDLSMLIVLPNTKTGLPALEEKLRLTTLSQITQSLYET 296
            .  |:.::.|....::....||||||..:.|::|:||...|.:..:|.::....:.:....|:|.
Mouse   217 KALLRAQYGYFSQSSMTCQVLELPYKADEFSLVIILPTEDTSIEEVENQVTAPHVRRWFSELHEE 281

  Fly   297 KVALKLPRFKAEFQVELSEVFQKLGMSRMFSDQAEFGKMLQSPEPLKVSAIIHKAFIEVNEEGTE 361
            :|.:.|||||.|.:::|.|....|.::.:||...:...:..|.| :.||.::.|.|.|:||:|:|
Mouse   282 EVEVSLPRFKIEQKLDLKEALYSLNVTEIFSGGCDLSGITDSSE-VYVSRVMQKVFFEINEDGSE 345

  Fly   362 AAAATGMAVRRKRAIMSPEEPIEFFADHPFTYVLVH-QKDLPLFWGSVVRLEENTFASSEHDEL 424
            |||:||:.:   .||||..: .:|.|:|||.::|.| :.:..||.|.|...:..|....:.|.|
Mouse   346 AAASTGINI---PAIMSLTQ-TQFLANHPFLFILKHIRTESILFMGKVTDPDIQTTKGRDLDSL 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Da	NP_524955.2	SERPIN	45..408	CDD:238101	114/369 (31%)
Serpini2	NP_080736.2	neuroserpin	23..405	CDD:239003	117/387 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2434
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	233	1.000	Inparanoid score	I3407
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm11110
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3483
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.010