DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Da and SERPINI1

DIOPT Version :9

Sequence 1:	NP_524955.2	Gene:	Spn42Da / 49805	FlyBaseID:	FBgn0265137	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001116224.1	Gene:	SERPINI1 / 5274	HGNCID:	8943	Length:	410	Species:	Homo sapiens

Alignment Length:	388	Identity:	134/388 - (34%)
Similarity:	217/388 - (55%)	Gaps:	17/388 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LALFSINVYGKLSGQKPGENIVFSPFSIQTCAAMARLGAENETATQLDQGLG---LASSDPEQIA 106
            :|..|:|:|.:|......|||:|||.||.....|..|||:..|..::...:|   |.:.:.....
Human    26 IADLSVNMYNRLRATGEDENILFSPLSIALAMGMMELGAQGSTQKEIRHSMGYDSLKNGEEFSFL 90

  Fly   107 HSFHQVLAAYQDSQILRIANKIFVMDGYQLRQEFDQLLSKQFLSAAQSVDFSKNVQAAATINNWV 171
            ..|..::.|.:...:::|||.:||.:|:.:.:||.|::.|.|.:|...||||:||..|..||.||
Human    91 KEFSNMVTAKESQYVMKIANSLFVQNGFHVNEEFLQMMKKYFNAAVNHVDFSQNVAVANYINKWV 155

  Fly   172 EQRTNHLIKDLVPADVLNSESRLVLVNAIHFKGTWQHQFAKHLTRPDTFHLDGERTVQVPMMSLK 236
            |..||:|:||||.....::.:.|.|:||::|||.|:.||....||..:|..|.|..||:|||..:
Human   156 ENNTNNLVKDLVSPRDFDAATYLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQ 220

  Fly   237 ERFRYADLP--ALDA----MALELPYKDSDLSMLIVLPNTKTGLPALEEKLRLTTLSQITQSLYE 295
            ..|.|.:..  :.:|    ..||:||:..::||::||...:..|..||..::...:.:...|:.:
Human   221 GEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLVLSRQEVPLATLEPLVKAQLVEEWANSVKK 285

  Fly   296 TKVALKLPRFKAEFQVELSEVFQKLGMSRMFSDQAEFGKMLQSPEPLKVSAIIHKAFIEVNEEGT 360
            .||.:.||||..|.:::|.:|.:.||::.:|...|....:..:.| :.:|..|||:|:||||||:
Human   286 QKVEVYLPRFTVEQEIDLKDVLKALGITEIFIKDANLTGLSDNKE-IFLSKAIHKSFLEVNEEGS 349

  Fly   361 EAAAATGMAVRRKRAIMSPEEPIEFFADHPFTYVLVHQK-DLPLFWGSVVRLEENTFASSEHD 422
            ||||.:||....:.|::.|    :...||||.:::.::: ...||.|.|:..|  |..:|.||
Human   350 EAAAVSGMIAISRMAVLYP----QVIVDHPFFFLIRNRRTGTILFMGRVMHPE--TMNTSGHD 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Da	NP_524955.2	SERPIN	45..408	CDD:238101	128/372 (34%)
SERPINI1	NP_001116224.1	neuroserpin	23..410	CDD:239003	134/388 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	227	1.000	Domainoid score	I2508
eggNOG	1	0.900	-	-		E33208_3BBFJ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H21045
Inparanoid	1	1.050	231	1.000	Inparanoid score	I3439
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	1	1.000	-	-		mtm9820
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3483
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.910