Protein Alignment Spn42Da and SERPINB10

DIOPT Version :9

• Sequence 1: NP_524955.2
• Gene: Spn42Da / 49805
• FlyBaseID: FBgn0265137
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_005015.1
• Gene: SERPINB10 / 5273
• HGNCID: 8942
• Length: 397
• Species: Homo sapiens
• Alignment Length: 392
• Identity: 134/392 - (34%)
• Similarity: 205/392 - (52%)
• Gaps: 43/392 - (10%)

  Fly    48 FSINVYGKLSGQKPGENIVFSPFSIQTCAAMARLGAENETATQL--------DQGLGLASSDPE- 103
            |::.:..||:....|:||.||.:||.|...:..|||:..||.|:        |||:   ..|||
Human    11 FALELSKKLAESAQGKNIFFSSWSISTSLTIVYLGAKGTTAAQMAQVLQFNRDQGV---KCDPES 72

  Fly   104 -------------QIAHSFHQVLAAY----QDSQILRIANKIFVMDGYQLRQEFDQLLSKQFLSA 151
                         :..||..|.|.:.    .|..:|:.||.|:....|....::.:.:...|.:.
Human    73 EKKRKMEFNLSNSEEIHSDFQTLISEILKPNDDYLLKTANAIYGEKTYAFHNKYLEDMKTYFGAE 137

  Fly   152 AQSVDF-SKNVQAAATINNWVEQRTNHLIKDLVPADVLNSESRLVLVNAIHFKGTWQHQFAKHLT 215
            .|.|:| ..:.|....||:|||::|...|::|:|.|.::|.:|::||||::|||.|:|||....|
Human   138 PQPVNFVEASDQIRKDINSWVERQTEGKIQNLLPDDSVDSTTRMILVNALYFKGIWEHQFLVQNT 202

  Fly   216 RPDTFHLDGERTVQVPMMSLKERFRYADLPALDAMALELPYKDSDLSMLIVLPNTKTGLPALEEK 280
            ....|.::...:..|.||.:|::.....:....|:.|:|.||..|||:||:||....||..||:.
Human   203 TEKPFRINETTSKPVQMMFMKKKLHIFHIEKPKAVGLQLYYKSRDLSLLILLPEDINGLEQLEKA 267

  Fly   281 LRLTTLSQITQS----LYETKVALKLPRFKAEFQVELSEVFQKLGMSRMFS-DQAEFGKMLQSPE 340
            :....|::.|.:    |||  |.|.||:||.|...:|......:|||..|| .:|:|..| .|..
Human   268 ITYEKLNEWTSADMMELYE--VQLHLPKFKLEDSYDLKSTLSSMGMSDAFSQSKADFSGM-SSAR 329

  Fly   341 PLKVSAIIHKAFIEVNEEGTEAAAATGMAVRRKRAIMSPEEPIEFFADHPFTYVLVHQK-DLPLF 404
            .|.:|.:.||||:|:||:||||||.:|..:..:..:.|    |||.|:|||.:.:.|.| :..||
Human   330 NLFLSNVFHKAFVEINEQGTEAAAGSGSEIDIRIRVPS----IEFNANHPFLFFIRHNKTNTILF 390

  Fly   405 WG 406
            :|
Human   391 YG 392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Da	NP_524955.2	SERPIN	45..408	CDD:238101	134/392 (34%)
SERPINB10	NP_005015.1	PAI-2	4..397	CDD:239013	134/392 (34%)
		Nuclear localization signal	74..77		0/2 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	1	1.000	-	-		mtm8652
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3483
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.860