DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Da and SERPINB5

DIOPT Version :9

Sequence 1:	NP_524955.2	Gene:	Spn42Da / 49805	FlyBaseID:	FBgn0265137	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_002630.2	Gene:	SERPINB5 / 5268	HGNCID:	8949	Length:	375	Species:	Homo sapiens

Alignment Length:	372	Identity:	96/372 - (25%)
Similarity:	197/372 - (52%)	Gaps:	40/372 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 FSINVYGKLSGQKPGENIVFSPFSIQTCAAMARLGAENETATQLDQ------------GLGLASS 100
            |:::::.:|..::|..|::|||..:.|..::|::||:.:||.::.|            |....:|
Human    11 FAVDLFKQLCEKEPLGNVLFSPICLSTSLSLAQVGAKGDTANEIGQVLHFENVKDVPFGFQTVTS 75

  Fly   101 DPEQIAHSFHQVLAAYQDSQILRIANKIFVMDGYQLRQEFDQLLSKQFLSAAQSVDF-SKNVQAA 164
            |..::: ||:.          |::..:::|.....|..||.....:.:....::||| .|..:..
Human    76 DVNKLS-SFYS----------LKLIKRLYVDKSLNLSTEFISSTKRPYAKELETVDFKDKLEETK 129

  Fly   165 ATINNWVEQRTNHLIKDLVPADVLNSESRLVLVNAIHFKGTWQHQFAKHLTRPDTFHLDGERTVQ 229
            ..|||.::..|:...::::..:.:|.::::::|||.:|.|.|..:|::..|:...|.::...|..
Human   130 GQINNSIKDLTDGHFENILADNSVNDQTKILVVNAAYFVGKWMKKFSESETKECPFRVNKTDTKP 194

  Fly   230 VPMMSLKERFRYADLPALDAMALELPYKDSDLSMLIVLP----NTKTGLPALEEKLRLTTLSQIT 290
            |.||:::..|...::.:::...:|||:::..|||.|:||    :..|||..:|::|...:|||.|
Human   195 VQMMNMEATFCMGNIDSINCKIIELPFQNKHLSMFILLPKDVEDESTGLEKIEKQLNSESLSQWT 259

  Fly   291 --QSLYETKVALKLPRFKAEFQVELSEVFQKLGMSRMFS-DQAEFGKMLQSPEPLKVSAIIHKAF 352
              .::...||.|.:|:||.|..::.....:.||:..:|| |.::|..|.:: :.:.:|.:|||..
Human   260 NPSTMANAKVKLSIPKFKVEKMIDPKACLENLGLKHIFSEDTSDFSGMSET-KGVALSNVIHKVC 323

  Fly   353 IEVNEEGTEAAAATGMAVRRKRAIMSPEEPIEFFADHPFTYVLVHQK 399
            :|:.|:|.::....|..:.:.:.        |..|||||.|::.|.|
Human   324 LEITEDGGDSIEVPGARILQHKD--------ELNADHPFIYIIRHNK 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Da	NP_524955.2	SERPIN	45..408	CDD:238101	96/372 (26%)
SERPINB5	NP_002630.2	maspin_like	4..375	CDD:239012	96/372 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8652
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.930