DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Da and Serpinb3b

DIOPT Version :9

Sequence 1:	NP_524955.2	Gene:	Spn42Da / 49805	FlyBaseID:	FBgn0265137	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_941373.1	Gene:	Serpinb3b / 383548	MGIID:	2683293	Length:	387	Species:	Mus musculus

Alignment Length:	402	Identity:	135/402 - (33%)
Similarity:	217/402 - (53%)	Gaps:	42/402 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 HTADVTMADAAHQEFARRLALFSINVYGKLSGQKPGENIVFSPFSIQTCAAMARLGAENETATQL 91
            |.|||.               |::.:|.:|  ::..:||.:||.|:.|..||.:|||:..|..|:
Mouse     5 HAADVK---------------FAVEMYRQL--RESDKNIFYSPISMMTALAMLQLGAKGNTEIQI 52

  Fly    92 DQGLGLASS------------DPEQIAHSFHQVLAAY---QDSQILRIANKIFVMDGYQLRQEFD 141
            ::.|....:            |.|.:...|.:::...   .|...|:.||.|:...|:...|.|.
Mouse    53 EKVLQFIETTKKTTEKSEHCDDEENVHEQFQKLITQLNKSNDDYDLKAANSIYGAKGFPFLQTFL 117

  Fly   142 QLLSKQFLSAAQSVDFS-KNVQAAATINNWVEQRTNHLIKDLVPADVLNSESRLVLVNAIHFKGT 205
            :.:.:.:.:..:|:||. ...::...||:|||.:||..||||.|:..|:|.:.||||||::|||.
Mouse   118 EDIKEYYQAKVESLDFEHATEESEKKINSWVESKTNGKIKDLFPSGSLSSSTILVLVNAVYFKGQ 182

  Fly   206 WQHQFAKHLTRPDTFHLDGERTVQVPMMSLKERFRYADLPALDAMALELPYKDSDLSMLIVLPNT 270
            |..:|.::.||.:.|.|:...:..|.||..:.:|.::.|..:.|..:|:|||..||||.::||..
Mouse   183 WNRKFNENHTREEKFWLNKNTSKPVQMMKQRNKFNFSFLGDVHAQIVEIPYKGKDLSMFVLLPME 247

  Fly   271 KTGLPALEEKLRLTTLSQ--ITQSLYETKVALKLPRFKAEFQVELSEVFQKLGMSRMFSDQ-AEF 332
            ..||..|||:|....|.:  ..::::.|::.|.|||||.|.:.:|....:.:||...|..| |:|
Mouse   248 IDGLKQLEEQLTTDKLLEWIKAENMHLTELYLSLPRFKVEEKYDLQVPLEHMGMVDAFDPQKADF 312

  Fly   333 GKMLQSPEPLKVSAIIHKAFIEVNEEGTEAAAATGMAVRRKRAIMSPEEPIEFFADHPFTYVLVH 397
            ..|...| .|.||.::||:|:||||||||||||||:.|    ::.|.:...:|..||||.:.::|
Mouse   313 SGMSSIP-GLVVSKVLHKSFVEVNEEGTEAAAATGVEV----SVRSAQIAEDFCCDHPFLFFIIH 372

  Fly   398 Q-KDLPLFWGSV 408
            : .:..||:|.:
Mouse   373 RMTNSILFFGRI 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Da	NP_524955.2	SERPIN	45..408	CDD:238101	131/382 (34%)
Serpinb3b	NP_941373.1	SERPIN	6..387	CDD:294093	134/401 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBFJ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	1	1.000	-	-		otm44262
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.730