DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Da and Serpinb6b

DIOPT Version :9

Sequence 1:	NP_524955.2	Gene:	Spn42Da / 49805	FlyBaseID:	FBgn0265137	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	XP_038951899.1	Gene:	Serpinb6b / 364705	RGDID:	1310452	Length:	388	Species:	Rattus norvegicus

Alignment Length:	376	Identity:	120/376 - (31%)
Similarity:	189/376 - (50%)	Gaps:	35/376 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 FSINVYGKLSGQKPGENIVFSPFSIQTCAAMARLGAENETATQLDQGL------GLASSDPEQIA 106
            |:.|:. |..|:...:|::|||.||.:..||..:||:..||.|:.|.|      |..|.|..|
  Rat    11 FAFNLL-KTLGEDSSKNVLFSPLSISSGLAMVFMGAKGTTAHQMIQALSLDKCSGRGSRDVHQ-- 72

  Fly   107 HSFHQVLAAYQDS---QILRIANKIFVMDGYQLRQEFDQLLSKQFLSAAQSVDF-SKNVQAAATI 167
             .|..:||....:   .:|:.||::|....:.:...|.....|.:.:..:.:|| ....|:...|
  Rat    73 -GFQSLLAKVNKTGTQYLLKTANRLFGEKTFDILASFKDACRKFYEAEMEELDFKGAPEQSRQHI 136

  Fly   168 NNWVEQRT-----------NHLIKDLVPADVLNSESRLVLVNAIHFKGTWQHQFAKHLTRPDTFH 221
            |.||.::|           ...|.:|:.:..:|:.:.|||||||:|||.|:.||.|..|:...|.
  Rat   137 NTWVAKKTEGQSISLNWNSQKKITELLSSGSVNANTPLVLVNAIYFKGNWKKQFNKEDTQEMPFK 201

  Fly   222 LDGERTVQVPMMSLKERFRYADLPALDAMALELPYKDSDLSMLIVLPNTKTGLPALEEKLRLTTL 286
            :.......|.||..|..|:...:..:....|.|||..::|:|:|:||:....|..:|:::.....
  Rat   202 VTKNEEKPVKMMFKKSTFKMTYVEEISTTILLLPYVGNELNMIIMLPDEHIELRMVEKEITYKKF 266

  Fly   287 SQIT--QSLYETKVALKLPRFKAEFQVELSEVFQKLGMSRMFSD-QAEFGKMLQSPEPLKVSAII 348
            .:.|  ..:.|.:|.:.||:||.|...::.:|..:|||:..|.. .|:|.. :.|.|.|.:|.:|
  Rat   267 IEWTSLDKMEEREVEVFLPKFKLEENHDMKDVLHRLGMTDAFEQGMADFSG-IASKEGLFLSKVI 330

  Fly   349 HKAFIEVNEEGTEAAAATGMAVRRKRAIMSPEEPIEFFADHPFTYVLVHQK 399
            ||:|:|||||||||||||...|..:  .|.|    .|.|:|||.:.:.|.:
  Rat   331 HKSFVEVNEEGTEAAAATAANVTFR--CMVP----YFCANHPFLFFIQHSR 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Da	NP_524955.2	SERPIN	45..408	CDD:238101	120/376 (32%)
Serpinb6b	XP_038951899.1	serpin	1..388	CDD:422956	120/376 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBFJ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	1	1.000	-	-		mtm12319
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.730