DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Da and serpina1

DIOPT Version :9

Sequence 1:	NP_524955.2	Gene:	Spn42Da / 49805	FlyBaseID:	FBgn0265137	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	XP_017207927.1	Gene:	serpina1 / 322701	ZFINID:	ZDB-GENE-030131-1421	Length:	433	Species:	Danio rerio

Alignment Length:	393	Identity:	122/393 - (31%)
Similarity:	201/393 - (51%)	Gaps:	28/393 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PVHTADVTMADAAHQEFARRLALFSINVYGKLS----GQKPGENIVFSPFSIQTCAAMARLGAEN 85
            |.|..    .||.|. .|...|.|:.::|.||:    ||  |:||.|||..|....::..:||:.
Zfish    55 PSHKG----VDACHL-LAPHNADFAFSLYKKLASNPDGQ--GKNIFFSPVGISMALSLLAVGAKA 112

  Fly    86 ETATQLDQGLGLASSDPEQI----AHSFHQVLAAYQDSQILRIANKIFVMDGYQLRQEFDQLLSK 146
            .|.:|:..|||.::..|||:    .|..| :|...||:..|.....:.:.||:::..:|.:....
Zfish   113 STLSQIYSGLGYSALTPEQVNEGYEHLLH-MLGHSQDAMQLEAGAGVAIRDGFKVVDQFLKDAQH 176

  Fly   147 QFLSAAQSVDFSKNVQAAATINNWVEQRTNHLIKDLVPADVLNSESRLVLVNAIHFKGTWQHQFA 211
            .:.|.|..|||||...|||.||.::.::|:..|.::|..  |::::.::|:|.::|:|.|:..|.
Zfish   177 YYNSEAFGVDFSKPEIAAAEINKFIARKTHDKITNMVKD--LDADTVMMLINYMYFRGKWEKPFD 239

  Fly   212 KHLTRPDTFHLDGERTVQVPMMSLKERFRYADLPALDAMALELPYKDSDLSMLIVLPNTKTGLPA 276
            ..||....|.:|.:.||||.||....|:.....|......:.:||| .:.||:||||:... :..
Zfish   240 AKLTHKADFKVDQDTTVQVDMMKRTGRYDIYQDPVNQTTVMMVPYK-GNTSMMIVLPDDGK-MKE 302

  Fly   277 LEEKLRLTTLSQITQSLYETKVALKLPRFKAEFQVELSEVFQKLGMSRMFSDQAEFGKMLQSPEP 341
            |||.:....|......|:.:.|.|.:|:|......:|..:.:.:||:..|:|:|:|..|.:..:
Zfish   303 LEESICRHHLKNWHDKLFRSSVDLFMPKFSISATSKLDGILKDMGMTDAFNDKADFSGMTEEVK- 366

  Fly   342 LKVSAIIHKAFIEVNEEGTEAAAATGMAVRRKRAIMSPEEPIEFFADHPFTYVLVHQKDLP-LFW 405
            :|||.::|:|.:.|:|:||||||.|.:      .||....|.....:.||..::|....:. ||.
Zfish   367 VKVSQVLHQAVMSVDEKGTEAAAITTI------EIMPMSLPDTVILNRPFLVLIVEDSTMSILFM 425

  Fly   406 GSV 408
            |.:
Zfish   426 GKI 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Da	NP_524955.2	SERPIN	45..408	CDD:238101	116/371 (31%)
serpina1	XP_017207927.1	alpha-1-antitrypsin_like	69..428	CDD:239011	116/372 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010