DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn42Da and Serpine3

DIOPT Version :9

Sequence 1:	NP_524955.2	Gene:	Spn42Da / 49805	FlyBaseID:	FBgn0265137	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	XP_017171543.1	Gene:	Serpine3 / 319433	MGIID:	2442020	Length:	404	Species:	Mus musculus

Alignment Length:	400	Identity:	106/400 - (26%)
Similarity:	176/400 - (44%)	Gaps:	34/400 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLPLLGLALFPFPPVHTADVTMADAAHQEFARRLAL----FSINVYGKLSGQKPGENIVFSPFSI 72
            :||||.:..|......:|      ......:..|.|    |::::|...:.::.|.|.|.||.|:
Mouse     1 MLPLLQVTFFLLSSCFSA------GGGSPLSEGLWLLKTEFALHLYRSAAAERNGTNFVISPASV 59

  Fly    73 QTCAAMARLGAENETATQLDQGLGLASSDPEQIAHSFHQVLAAYQDSQI---LRIANKIFVMDGY 134
            .....:.:.||...|..||...||....|| ::....|.|.....:|..   :.:|..:|:..|.
Mouse    60 SLSLEILQFGARGNTGWQLAGALGYTVQDP-RVKEFLHAVYTTRHNSSQGVGMELACTLFMQTGT 123

  Fly   135 QLRQEFDQLLSKQFLSAAQSVDFSKNVQAAATINNWVEQRTNHLIKDLVP----ADVLNSESRLV 195
            .|...|.:.:|:...|:.::.|||:........:....:::.....| .|    ||.|:::  |.
Mouse   124 SLSPCFVEQVSRWANSSLEAADFSEPNSTTTEASKVTSRQSTGEGPD-SPLWGRADALSTQ--LS 185

  Fly   196 LVNAIHFKGTWQHQFAKHLTRPDTFHLDGERTVQVPMMSLKERFRYA---DLPALDAMALELPYK 257
            :::.:.|:.|||.:|:..|......|..| ..:|||.|.......|.   |....:...|||.|.
Mouse   186 IMSTMTFQSTWQKRFSVVLQPLPFTHAHG-LVLQVPAMHQVAEVSYGQFQDAAGHEIAVLELLYL 249

  Fly   258 DSDLSMLIVLPNTK-TGLPALEEKLRLTTLSQITQSLYETKVALKLPRFKAEFQVELSEVFQKLG 321
            ....|:|:|||..| |.|..:|..|....|...|..|...::.:.|||||.:.|.::..:.:..|
Mouse   250 GRVASLLLVLPQDKGTPLDHIEPHLTARVLHLWTTRLKRARMDVFLPRFKIQNQFDVKSILRSWG 314

  Fly   322 MSRMFSDQAEFGKMLQSPEPLKVSAIIHKAFIEVNEEGTEAAAATG-MAVRRKRAIMSPEEPIEF 385
            ::.:|.......|.:...:...||.:.|||.:|::||||.::|||. :.:||.|.       ..|
Mouse   315 ITDLFDPLKANLKGISGQDGFYVSQLTHKAKMELSEEGTRSSAATAVLLLRRSRT-------SAF 372

  Fly   386 FADHPFTYVL 395
            .||.||.::|
Mouse   373 KADRPFIFLL 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Da	NP_524955.2	SERPIN	45..408	CDD:238101	99/366 (27%)
Serpine3	XP_017171543.1	serpin	20..388	CDD:393296	99/374 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020