DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Da and Serpina6

DIOPT Version :9

Sequence 1:	NP_524955.2	Gene:	Spn42Da / 49805	FlyBaseID:	FBgn0265137	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001009663.1	Gene:	Serpina6 / 299270	RGDID:	1595901	Length:	396	Species:	Rattus norvegicus

Alignment Length:	429	Identity:	103/429 - (24%)
Similarity:	185/429 - (43%)	Gaps:	61/429 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDYRLVPCGCWLLPLLGLALFPFPPVHTADVTMADA-------AHQEFARRLALFSINVYGKLSG 58
            |...|..|..||.              |:.:..|.|       :|:..|.....|:.|:|.:|..
  Rat     1 MSLALYTCLLWLC--------------TSGLWTAQASTNESSNSHRGLAPTNVDFAFNLYQRLVA 51

  Fly    59 QKPGENIVFSPFSIQTCAAMARLGAENETATQLDQGLG--LASSDPEQIAHSFHQV--LAAYQDS 119
            ..|.:|.:.||.||....||..||:   ..||..|.||  |..:...:|..||..:  |....|:
  Rat    52 LNPDKNTLISPVSISMALAMVSLGS---AQTQSLQSLGFNLTETSEAEIHQSFQYLNYLLKQSDT 113

  Fly   120 QI-LRIANKIFVMDGYQLRQEFDQLLSKQFLSAAQSVDFSKNVQAAATINNWVEQRT----NHLI 179
            .: :.:.|.:|::...:|:..|...:.:.:.|.|.::||....:|:..||..|:.:|    .|:.
  Rat   114 GLEMNMGNAMFLLQKLKLKDSFLADVKQYYESEALAIDFEDWTKASQQINQHVKDKTQGKIEHVF 178

  Fly   180 KDLVPADVLNSESRLVLVNAIHFKGTWQHQFAKHLTRPDTFHLDGERTVQVPMMSLKERFRYADL 244
            .|      |:|.:..:|||.|..:|.|:..|:...||.:.|:::...||:||||.......|...
  Rat   179 SD------LDSPASFILVNYIFLRGIWELPFSPENTREEDFYVNETSTVKVPMMVQSGSIGYFRD 237

  Fly   245 PALDAMALELPYKDSDLSMLIVLPN---TKTGLPALEEKLRLTTLSQITQSLYETKVALKLPRFK 306
            .......:::.|..:..:..| ||:   ..|.:.||..    .|:.:..:.:...:|.|.:|:|.
  Rat   238 SVFPCQLIQMDYVGNGTAFFI-LPDQGQMDTVIAALSR----DTIDRWGKLMTPRQVNLYIPKFS 297

  Fly   307 AEFQVELSEVFQKLGMSRMFSDQAEF-GKMLQSPEPLKVSAIIHKAFIEVNEEGTEAAAATGMAV 370
            .....:|.::.:.|.:..:.::|::| |.....|..|   .::|||.::: :||.....:|..|.
  Rat   298 ISDTYDLKDMLEDLNIKDLLTNQSDFSGNTKDVPLTL---TMVHKAMLQL-DEGNVLPNSTNGAP 358

  Fly   371 RRKRAIMSPEEPIEFFADHPFTYVLVHQKDLPLFWGSVV 409
            ...|:     ||::...:.||..:|..:    ..|.|::
  Rat   359 LHLRS-----EPLDIKFNKPFILLLFDK----FTWSSLM 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Da	NP_524955.2	SERPIN	45..408	CDD:238101	92/375 (25%)
Serpina6	NP_001009663.1	alpha-1-antitrypsin_like	37..392	CDD:239011	93/379 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.110