DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Da and Serpinb1b

DIOPT Version :9

Sequence 1:	NP_524955.2	Gene:	Spn42Da / 49805	FlyBaseID:	FBgn0265137	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_766640.1	Gene:	Serpinb1b / 282663	MGIID:	2445361	Length:	382	Species:	Mus musculus

Alignment Length:	376	Identity:	138/376 - (36%)
Similarity:	203/376 - (53%)	Gaps:	20/376 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LFSINVYGKLSGQKPGENIVFSPFSIQTCAAMARLGAENETATQLDQGLGLASSDPEQIAHSFHQ 111
            ||::.::..|....|..||.||||||.:..||..|||:..||.||.:.|..   |..:..||..|
Mouse    10 LFTLELFHTLKESSPTGNIFFSPFSISSSLAMVFLGAKGSTAAQLSKTLHF---DSVEDIHSCFQ 71

  Fly   112 VLAAYQD----SQILRIANKIFVMDGYQLRQEFDQLLSKQFLSAAQSVDFS-KNVQAAATINNWV 171
            .|.|...    |..|::||:::....|....||.....|.:.:...:|||. .:..|...||.||
Mouse    72 SLTAEVSKLGASHTLKLANRLYGEKTYNFLPEFLASTQKMYSADLAAVDFQHASEDARKEINQWV 136

  Fly   172 EQRTNHLIKDLVPADVLNSESRLVLVNAIHFKGTWQHQFAKHLTRPDTFHLDGERTVQVPMMSLK 236
            :.:|...|.:|:...|::|.::|||||||:|||.|:.||....|....|.|:.:.|..|.||..|
Mouse   137 KGQTEGKIPELLAKGVVDSMTKLVLVNAIYFKGIWEEQFMTRETINAPFRLNKKDTKTVKMMYQK 201

  Fly   237 ERFRYADLPALDAMALELPYKDSDLSMLIVLP----NTKTGLPALEEKLRLTTLSQIT--QSLYE 295
            ::|.:..:..|....||:||:..:|||:|:||    :..|||..:||:|.|..|.:.|  ::|..
Mouse   202 KKFPFGYISDLKCKVLEMPYQGGELSMVILLPEDIEDESTGLKKIEEQLTLGKLHEWTKHENLRN 266

  Fly   296 TKVALKLPRFKAEFQVELSEVFQKLGMSRMFSD-QAEFGKMLQSPEPLKVSAIIHKAFIEVNEEG 359
            ..|.:||||||.|....|:.....||:..:||. :|:...|..|.: |.||.|:||:|::|||:|
Mouse   267 IDVHVKLPRFKMEESYILNSNLCCLGVQDLFSSGKADLSGMSGSRD-LFVSKIVHKSFVDVNEQG 330

  Fly   360 TEAAAATGMAVR-RKRAIMSPEEPIEFFADHPFTYVLVHQKDL-PLFWGSV 408
            ||||||||..:: ....:.:|:|  .|..||||.:.:.|.... .:|:|.|
Mouse   331 TEAAAATGGIIQVLCEKMPTPQE--VFTVDHPFLFFIRHNPTANMIFFGRV 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Da	NP_524955.2	SERPIN	45..408	CDD:238101	137/374 (37%)
Serpinb1b	NP_766640.1	serpinB1_LEI	1..382	CDD:381028	138/376 (37%)
Serpinb1b	NP_766640.1	CARD-binding motif (CBM). /evidence=ECO:0000250\|UniProtKB:P30740	352..382		10/30 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBFJ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	1	1.000	-	-		otm44262
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.830